{"id":"W3014519835","doi":"10.1021/acs.analchem.9b05740","title":"Aptamer Binding Assay for the E Antigen of Hepatitis B Using Modified Aptamers with G-Quadruplex Structures","year":2020,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Li Ka Shing Institute of Virology, University of Alberta; Canadian Institutes of Health Research; Alberta Innovates; Canada Research Chairs; Alberta Health; Natural Sciences and Engineering Research Council of Canada","keywords":"Aptamer; Chemistry; G-quadruplex; HBeAg; Molecular biology; Ligand binding assay; Systematic evolution of ligands by exponential enrichment; Virology; Hepatitis B virus; Biochemistry; DNA; RNA; Biology; Virus; HBsAg; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000948381,0.0009334045,0.0006279554,0.0005300998,0.0002551621,0.0002770017,0.000724057,0.001126794,0.001112291],"category_scores_gemma":[0.0008066994,0.0004396566,0.0005061383,0.0003171681,0.0003095669,0.0002818207,0.0003995681,0.001116541,0.0006576436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003837472,"about_ca_system_score_gemma":0.0002180698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005422441,"about_ca_topic_score_gemma":0.0008156784,"domain_scores_codex":[0.9987628,0.0003858864,0.00008753802,0.0003246253,0.0003407713,0.00009834451],"domain_scores_gemma":[0.9994565,0.0002544696,0.00006305776,0.00005476323,0.0001156812,0.00005564515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002882348,0.00003434772,0.0001138626,0.00003320829,0.00001187081,0.00001086725,0.00002245154,0.0000828338,0.9986921,0.00002988271,0.00001922821,0.0009205827],"study_design_scores_gemma":[0.00001944856,0.0005366926,0.001831175,0.000008671638,0.00002853437,0.0002553306,0.00001645377,0.003616555,0.9928086,0.00004910133,0.0008124117,0.0000171189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7429256,0.004058294,0.2489919,0.0001961164,0.0001181962,0.0003801481,0.0004042702,0.0008059233,0.002119576],"genre_scores_gemma":[0.7236033,0.002078738,0.263789,0.0004079435,0.00005569114,0.00056832,0.00137997,0.00006064745,0.008056403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001126794,"threshold_uncertainty_score":0.005015612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0279589552192536,"score_gpt":0.2923683693821963,"score_spread":0.2644094141629427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}