{"id":"W3014619333","doi":"10.1038/s41467-020-15423-5","title":"GPR56/ADGRG1 is associated with response to antidepressant treatment","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; St. Michael's Hospital; University of Toronto; University Health Network; McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Fondation de France; Government of Ontario; Agence Nationale de la Recherche; H. Lundbeck A/S; Government of Canada; National Alliance for Research on Schizophrenia and Depression; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Ontario Brain Institute","keywords":"Antidepressant; Downregulation and upregulation; Norepinephrine; Depression (economics); Prefrontal cortex; Gene knockdown; Serotonin; Internal medicine; Endocrinology; Reuptake inhibitor; Medicine; Psychology; Pharmacology; Hippocampus; Neuroscience; Receptor; Chemistry; Dopamine; Apoptosis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001137126,0.0001140046,0.0001163567,0.00002166681,0.0001565739,0.00002582419,0.0004614874,0.0001877178,0.00003963459],"category_scores_gemma":[0.0002137905,0.00009110902,0.0000498164,0.0001528322,0.0000291514,0.000002525429,0.0001647334,0.0001760785,0.00001682009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002252628,"about_ca_system_score_gemma":0.00007073361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009576735,"about_ca_topic_score_gemma":0.00006351848,"domain_scores_codex":[0.9993054,0.0001441106,0.0001111235,0.0002123852,0.00009496798,0.0001320647],"domain_scores_gemma":[0.9988279,0.00004751844,0.00005255361,0.0008361328,0.000116644,0.0001193051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004004582,0.0001150256,0.0009038512,0.000001229411,0.0001385149,0.000002063449,0.000447157,0.00004293512,0.9890646,0.0001832616,0.007988742,0.0007121479],"study_design_scores_gemma":[0.0007342848,0.001203697,0.002516566,0.00002201742,0.00004622386,0.000003821602,0.0001529466,0.0002275783,0.4379607,0.0000117338,0.5568755,0.0002448833],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9718962,0.003993827,0.001015433,0.02120678,0.00005904917,0.0004362378,0.0001704433,0.00005236673,0.001169643],"genre_scores_gemma":[0.9924187,0.0002629872,0.003439185,0.003313256,0.00004307548,0.00003786359,0.0002253262,0.0000199985,0.0002396212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5511039,"threshold_uncertainty_score":0.3715318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02301853030344028,"score_gpt":0.2898290879225338,"score_spread":0.2668105576190936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}