{"id":"W3014619333","doi":"10.1038/s41467-020-15423-5","title":"GPR56/ADGRG1 is associated with response to antidepressant treatment","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; St. Michael's Hospital; University of Toronto; University Health Network; McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Fondation de France; Government of Ontario; Agence Nationale de la Recherche; H. Lundbeck A/S; Government of Canada; National Alliance for Research on Schizophrenia and Depression; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Ontario Brain Institute","keywords":"Antidepressant; Downregulation and upregulation; Norepinephrine; Depression (economics); Prefrontal cortex; Gene knockdown; Serotonin; Internal medicine; Endocrinology; Reuptake inhibitor; Medicine; Psychology; Pharmacology; Hippocampus; Neuroscience; Receptor; Chemistry; Dopamine; Apoptosis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001536449,0.0001725215,0.0003778122,0.0002851553,0.0001356163,0.000278734,0.0001533428,0.0003168221,0.00207671],"category_scores_gemma":[0.0005619258,0.00008313716,0.0002726358,0.0003499713,0.0001545566,0.0001068843,0.0001710417,0.0003274388,0.0003487627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001840188,"about_ca_system_score_gemma":0.00005499715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005768531,"about_ca_topic_score_gemma":0.0005565329,"domain_scores_codex":[0.9998839,0.00002329241,0.00001402618,0.00003990727,0.00001787731,0.00002095604],"domain_scores_gemma":[0.99967,0.00003243376,0.0002032779,0.00002101145,0.00002017686,0.00005306944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005981573,0.0001539905,0.9205204,0.0001493399,0.0003614982,0.0009567419,0.00009541037,0.0001564324,0.04337765,0.000148741,0.001245252,0.02685307],"study_design_scores_gemma":[0.00001845324,0.0001163628,0.9982203,0.000006661775,0.00003896732,0.0005201585,0.00002786003,0.0001528898,0.0004437549,0.00004518353,0.0004059296,0.000003487438],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976239,0.0006921949,0.0001239424,0.0001337287,0.00002161759,0.0000108823,0.0004319527,0.00001494762,0.0009468904],"genre_scores_gemma":[0.9987835,0.0001586545,0.0001449271,0.0000704502,0.0000141211,0.000009124688,0.0003418401,0.00000351024,0.0004739258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00207671,"threshold_uncertainty_score":0.006947279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02301853030344028,"score_gpt":0.2898290879225338,"score_spread":0.2668105576190936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}