{"id":"W3014622064","doi":"10.1016/j.bbrc.2020.03.135","title":"Magnetic targeting of oncolytic VSV-based therapies improves infection of tumor cells in the presence of virus-specific neutralizing antibodies in vitro","year":2020,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal; Ottawa Hospital; University of Ottawa","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Terry Fox Research Institute; Ontario Institute for Cancer Research","keywords":"Oncolytic virus; Immune system; Virus; Antibody; Cancer research; Tumor microenvironment; Virology; Cancer cell; In vitro; Cancer; Neutralizing antibody; Immunology; Medicine; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001725227,0.0003234624,0.0002830591,0.000153622,0.0001695601,0.0003356879,0.0002142803,0.0002525631,0.0008074124],"category_scores_gemma":[0.0001750577,0.0001366461,0.0001475109,0.00009771065,0.0001969047,0.0001916433,0.000171117,0.0004294029,0.0002364715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004336185,"about_ca_system_score_gemma":0.0002646579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001488221,"about_ca_topic_score_gemma":0.001507068,"domain_scores_codex":[0.9998243,0.00003011146,0.000008067098,0.00002864435,0.00005256417,0.00005626377],"domain_scores_gemma":[0.9999282,0.00002074539,0.00001548907,0.000006852225,0.00001400197,0.00001468205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005104036,0.00001683895,0.00003178309,0.00001349985,0.000002666215,0.000007118218,0.00001123302,0.00007067827,0.9990141,0.00009225123,0.00003223326,0.0006564515],"study_design_scores_gemma":[0.000005602708,0.0001075099,0.0003843184,0.000001404815,0.000007830795,0.00003763552,0.000007004541,0.0006310195,0.9979554,0.00001916597,0.0008415275,0.000001549035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912579,0.001187345,0.005233724,0.0001022078,0.00004901389,0.00001802792,0.00006275438,0.00008624426,0.002002827],"genre_scores_gemma":[0.9962963,0.0003259404,0.001233895,0.00004176013,0.00001022766,0.000010627,0.0000955302,0.00001711384,0.00196854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001488221,"threshold_uncertainty_score":0.003146172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05758595878545709,"score_gpt":0.3482178015112068,"score_spread":0.2906318427257497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}