{"id":"W3014622477","doi":"10.1093/cvr/cvaa077","title":"Effect of inclisiran, the small-interfering RNA against proprotein convertase subtilisin/kexin type 9, on platelets, immune cells, and immunological biomarkers: a pre-specified analysis from ORION-1","year":2020,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Daiichi-Sankyo; Medicines Company; CSL Behring; Daiichi Sankyo Europe; AstraZeneca","keywords":"Immunogenicity; Medicine; Immune system; PCSK9; Immunology; Kexin; Proprotein convertase; Pharmacology; Antibody; Internal medicine; Lipoprotein; Cholesterol; LDL receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006613211,0.0004713532,0.0007813746,0.0002837459,0.0001504162,0.0002832721,0.0002445821,0.0002857696,0.001590069],"category_scores_gemma":[0.0004265227,0.0001466949,0.000610441,0.0001554707,0.0003035569,0.0001876474,0.0001970307,0.0008663908,0.0001838699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002025662,"about_ca_system_score_gemma":0.0003254389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001910812,"about_ca_topic_score_gemma":0.0004751867,"domain_scores_codex":[0.9996876,0.0001059827,0.00003888803,0.00004788823,0.00007501056,0.00004480358],"domain_scores_gemma":[0.999629,0.0001035073,0.0001040416,0.00005576096,0.00004942881,0.00005822648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.06269486,0.00624029,0.007040538,0.0006492208,0.0003013857,0.0003783769,0.000199487,0.0007942806,0.8473617,0.0001207257,0.0004155855,0.07380351],"study_design_scores_gemma":[0.008689187,0.4453486,0.08153503,0.00004686181,0.0007620243,0.002163631,0.0001060896,0.001252094,0.4536795,0.0001011608,0.006268143,0.00004773105],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979197,0.0007430038,0.0003869922,0.00003321404,0.00001118058,0.0001699976,0.0002111798,0.0000159038,0.000508766],"genre_scores_gemma":[0.9951445,0.0008104935,0.001292741,0.0001075524,0.00002848538,0.0002315758,0.001133459,0.000009208158,0.001241933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001590069,"threshold_uncertainty_score":0.005319297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05915837214004183,"score_gpt":0.3160306684722604,"score_spread":0.2568722963322185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}