{"id":"W3014622477","doi":"10.1093/cvr/cvaa077","title":"Effect of inclisiran, the small-interfering RNA against proprotein convertase subtilisin/kexin type 9, on platelets, immune cells, and immunological biomarkers: a pre-specified analysis from ORION-1","year":2020,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Daiichi-Sankyo; Medicines Company; CSL Behring; Daiichi Sankyo Europe; AstraZeneca","keywords":"Immunogenicity; Medicine; Immune system; PCSK9; Immunology; Kexin; Proprotein convertase; Pharmacology; Antibody; Internal medicine; Lipoprotein; Cholesterol; LDL receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004993747,0.0003404639,0.001335346,0.0003933503,0.0002414698,0.0001115224,0.0006419215,0.0002779933,0.0002135739],"category_scores_gemma":[0.002298606,0.0002148033,0.001183184,0.002190176,0.0007020177,0.00004878015,0.0008918013,0.001517439,0.00009514426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001368096,"about_ca_system_score_gemma":0.0001313337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008960042,"about_ca_topic_score_gemma":0.000008860282,"domain_scores_codex":[0.9929629,0.002873984,0.0005618394,0.0009655319,0.001957993,0.0006777535],"domain_scores_gemma":[0.9960266,0.001334345,0.00007658814,0.001659154,0.0005317698,0.000371583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03051752,0.0001926568,0.0008682507,0.0007047908,0.01913449,0.001691696,0.0007901967,0.0002345969,0.7753159,0.0000109203,0.0001472679,0.1703918],"study_design_scores_gemma":[0.004320463,0.005240577,0.009991959,0.0002566815,0.00105658,0.00001236931,0.0003805697,0.004320444,0.9694118,0.000005248025,0.004734494,0.0002688382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737037,0.02254479,0.0002095213,0.0004614786,0.00005118713,0.002421624,0.00002905875,0.00005447031,0.0005241748],"genre_scores_gemma":[0.9968706,0.002520419,0.0001063246,0.00004677472,0.0001250086,0.00009602515,0.0001135657,0.00005682559,0.0000645018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1940959,"threshold_uncertainty_score":0.8759426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05915837214004183,"score_gpt":0.3160306684722604,"score_spread":0.2568722963322185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}