{"id":"W3014673625","doi":"10.1126/scisignal.aaz0344","title":"Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety","year":2020,"lang":"en","type":"article","venue":"Science Signaling","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Canada Foundation for Innovation; Princess Margaret Cancer Foundation; Heart and Stroke Foundation of Canada","keywords":"Calmodulin; Moiety; Chemistry; Cell biology; Biophysics; Biochemistry; Biology; Stereochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004225534,0.0001568903,0.0001670621,0.0000534944,0.0001835782,0.00005022927,0.0002912568,0.0001004179,0.00004387446],"category_scores_gemma":[0.0002598031,0.0001552399,0.00006501374,0.0005805487,0.0002126028,0.00002741291,0.0001341256,0.00008075925,0.000007459105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002112971,"about_ca_system_score_gemma":0.0001429485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009640236,"about_ca_topic_score_gemma":0.000001017957,"domain_scores_codex":[0.9984775,0.00005085633,0.0003303812,0.0004852712,0.000364624,0.0002913661],"domain_scores_gemma":[0.9992428,0.000008760318,0.0001616421,0.0001758744,0.0002133433,0.0001975454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003828388,0.00001565917,0.0001360559,0.00006069469,0.000007849942,0.000001456602,0.0001694935,0.0337506,0.964677,0.00004320988,0.00002681398,0.001072837],"study_design_scores_gemma":[0.0002988994,0.0001031545,0.00001155867,0.00005444264,0.000008296591,0.000004129057,0.00005370413,0.09235318,0.9054685,0.00001045107,0.001462802,0.0001709007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9052505,0.000397246,0.09355911,0.0001960022,0.00009808831,0.0002335137,0.00002413908,0.00003833193,0.000202994],"genre_scores_gemma":[0.998791,0.00003011878,0.0006438303,0.0002616196,0.0001444192,0.000006656888,0.00006845429,0.00001787892,0.00003602555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09354042,"threshold_uncertainty_score":0.6330501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01608748686437422,"score_gpt":0.2511231279259563,"score_spread":0.235035641061582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}