{"id":"W3014706061","doi":"10.1016/j.jconrel.2020.03.035","title":"Periphery-confined particulate systems for the management of neurodegenerative diseases and toxicity: Avoiding the blood-brain-barrier challenge","year":2020,"lang":"en","type":"review","venue":"Journal of Controlled Release","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institut National de la Recherche Scientifique","funders":"","keywords":"Blood–brain barrier; Toxicity; Medicine; Particulates; Neuroscience; Chemistry; Internal medicine; Psychology; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001786065,0.0004211965,0.002406017,0.00008247729,0.0003462085,0.000223037,0.0005752569,0.00009481655,0.00003316641],"category_scores_gemma":[0.0007434665,0.000193804,0.0009199174,0.0001738619,0.0001919049,0.00009648496,0.0001181081,0.0003473307,0.000004776273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005024194,"about_ca_system_score_gemma":0.0003064687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003545684,"about_ca_topic_score_gemma":6.574602e-7,"domain_scores_codex":[0.9958177,0.001325972,0.001622989,0.0003205125,0.0005715509,0.0003412935],"domain_scores_gemma":[0.9934112,0.003425175,0.002185152,0.000415019,0.0003097015,0.0002537461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02684234,0.003531202,0.00001156256,0.1282499,0.04169548,0.005633495,0.004435689,0.02408316,0.04702082,0.02564435,0.009951826,0.6829002],"study_design_scores_gemma":[0.0344619,0.002503312,0.00000463498,0.020473,0.06498417,0.0004426048,0.001696061,0.01948335,0.002487795,0.0001948754,0.8520254,0.001242865],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01003363,0.9839278,0.0002981466,0.001784727,0.0008079668,0.002987904,0.0001249286,0.00001430187,0.00002056882],"genre_scores_gemma":[0.08272953,0.9159241,0.00003667749,0.0001608451,0.000598434,0.0003104129,0.000001167329,0.00004963281,0.0001891575],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8420736,"threshold_uncertainty_score":0.7903096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02422354890739206,"score_gpt":0.2707230686424696,"score_spread":0.2464995197350776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}