{"id":"W3014800882","doi":"10.1021/acsabm.0c00130","title":"Stable Retinoid Analogue Targeted Dual pH-Sensitive Smart Lipid ECO/<i>pDNA</i> Nanoparticles for Specific Gene Delivery in the Retinal Pigment Epithelium","year":2020,"lang":"en","type":"article","venue":"ACS Applied Bio Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Eye Institute; Harrington Discovery Institute, University Hospitals; Foundation Fighting Blindness; Alcon Research Institute; Canadian Institute for Advanced Research","keywords":"Gene delivery; Retinal pigment epithelium; Genetic enhancement; Chemistry; Molecular biology; Biophysics; Retinal; Cell biology; Biochemistry; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000111732,0.0002313207,0.0001810618,0.0001019971,0.00009814721,0.0002074058,0.0001692529,0.0003524139,0.000457071],"category_scores_gemma":[0.0001061836,0.0001504875,0.0001778594,0.00006688164,0.0001856071,0.0002453264,0.0001780791,0.000300774,0.0002753203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002769996,"about_ca_system_score_gemma":0.0001598034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003761576,"about_ca_topic_score_gemma":0.0003938396,"domain_scores_codex":[0.9999061,0.00001423113,0.00000819787,0.00002951795,0.00002558213,0.00001635463],"domain_scores_gemma":[0.9999467,0.000007897033,0.00001848713,0.000006360537,0.00001044149,0.00001011796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001704895,0.000004570002,0.00002167412,0.00001776556,0.000001736747,0.00001660002,0.000005663681,0.00009846059,0.9992743,0.00005742438,0.00001212118,0.0004726147],"study_design_scores_gemma":[0.000003513712,0.00004326441,0.0001365002,0.000001017787,0.000003470505,0.0000406,0.000003416804,0.0007090895,0.9984586,0.000009950558,0.0005876053,0.00000291187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802644,0.001122769,0.01612368,0.00009697516,0.00003065056,0.0000700081,0.0001342956,0.0001360889,0.002021047],"genre_scores_gemma":[0.9863666,0.0005079866,0.01065239,0.00005896078,0.000006491735,0.00005349418,0.0001020414,0.00002839625,0.002223659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000457071,"threshold_uncertainty_score":0.002009749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01757187361562783,"score_gpt":0.217132392948399,"score_spread":0.1995605193327712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}