{"id":"W3014800882","doi":"10.1021/acsabm.0c00130","title":"Stable Retinoid Analogue Targeted Dual pH-Sensitive Smart Lipid ECO/<i>pDNA</i> Nanoparticles for Specific Gene Delivery in the Retinal Pigment Epithelium","year":2020,"lang":"en","type":"article","venue":"ACS Applied Bio Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Eye Institute; Harrington Discovery Institute, University Hospitals; Foundation Fighting Blindness; Alcon Research Institute; Canadian Institute for Advanced Research","keywords":"Gene delivery; Retinal pigment epithelium; Genetic enhancement; Chemistry; Molecular biology; Biophysics; Retinal; Cell biology; Biochemistry; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005406474,0.0002908288,0.0003311365,0.00003704032,0.0001243935,0.0001161569,0.0003111967,0.0001759627,0.00005292982],"category_scores_gemma":[0.00003306455,0.000229505,0.00007606424,0.0001282189,0.0001016616,0.000008361558,0.0001648557,0.00008020864,0.00007572745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000235698,"about_ca_system_score_gemma":0.00005783563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004131219,"about_ca_topic_score_gemma":0.00003229366,"domain_scores_codex":[0.9980942,0.0001350997,0.0004954974,0.0006134887,0.0001783503,0.0004833462],"domain_scores_gemma":[0.9992499,0.00003535444,0.0001678907,0.0003606616,0.00009940997,0.00008677555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001353163,0.00007304515,0.00004697058,0.0000291275,0.00004888088,0.00001137819,0.0003435137,0.00001651678,0.9885635,0.0001038854,0.009193727,0.0002162343],"study_design_scores_gemma":[0.0007807796,0.0004861866,0.001418834,0.00001173673,0.00002958477,0.000009403761,0.000439826,0.000002557025,0.9804055,0.0000524956,0.01606389,0.000299177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969831,0.0002069429,0.0001052251,0.001002071,0.0002240469,0.0007824259,0.0005507601,0.00001992056,0.0001254899],"genre_scores_gemma":[0.9933884,0.0004174994,0.0005345524,0.003446944,0.0009077039,0.0001785915,0.001060075,0.00003414601,0.00003204618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008158029,"threshold_uncertainty_score":0.9358944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01757187361562783,"score_gpt":0.217132392948399,"score_spread":0.1995605193327712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}