{"id":"W3014806119","doi":"10.1158/2159-8290.cd-19-1030","title":"Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes","year":2020,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":278,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"CRIS Cancer Foundation; Deutsche Kinderkrebsstiftung; NIHR Great Ormond Street Hospital Biomedical Research Centre; Deutsche Krebshilfe; Brain Tumour Charity; Medical Research Council; CHILDREN with CANCER UK; Australian Lions Childhood Cancer Research Foundation; Cure Brain Cancer Foundation; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; National Cancer Institute; Ira Sohn Research Conference Foundation; Making Headway Foundation; National Institutes of Health; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology; Marie-Josée and Henry R. Kravis Center for Molecular Oncology; American Lebanese Syrian Associated Charities; Lions Clubs International Foundation; Friedberg Charitable Foundation; Cancer Research UK; Children's Hospital Foundation","keywords":"Gene; Biology; Glioma; Cancer research; Oncology; Bioinformatics; Genetics; Medicine; Computational biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004448017,0.0002986702,0.0006683957,0.00006355227,0.000148379,0.00009860045,0.00009121331,0.00008370444,0.0001386084],"category_scores_gemma":[0.00003627123,0.0002264173,0.0001651349,0.0002329407,0.00007774463,0.0003285554,0.0001196786,0.0001450174,0.00001938559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001034317,"about_ca_system_score_gemma":0.0001061895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00153455,"about_ca_topic_score_gemma":0.00006236588,"domain_scores_codex":[0.9985377,0.00001937269,0.0003064764,0.0004919447,0.0002614045,0.0003830949],"domain_scores_gemma":[0.9990928,0.00009039543,0.0001200632,0.0002758648,0.0000440248,0.0003769032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002178552,0.0006504989,0.4848256,0.0001080979,0.0003750373,0.00007144603,0.0001737158,0.00001723654,0.5102604,0.00008094369,0.002875566,0.0003435432],"study_design_scores_gemma":[0.02586779,0.0004812121,0.629245,0.0001979471,0.0009726514,0.00003296392,0.0002217512,0.0009511136,0.2702272,0.00003892282,0.07096621,0.0007972777],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808557,0.007970309,0.0005184956,0.00810943,0.0002382058,0.0008088992,0.001384754,0.00008069698,0.00003352591],"genre_scores_gemma":[0.9931841,0.00181995,0.0008240379,0.002828477,0.0001791421,0.0003953348,0.0004161904,0.00004608219,0.0003067182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2400333,"threshold_uncertainty_score":0.9233028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02362995440538189,"score_gpt":0.2565559089169627,"score_spread":0.2329259545115808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}