{"id":"W3014806119","doi":"10.1158/2159-8290.cd-19-1030","title":"Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes","year":2020,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":278,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"CRIS Cancer Foundation; Deutsche Kinderkrebsstiftung; NIHR Great Ormond Street Hospital Biomedical Research Centre; Deutsche Krebshilfe; Brain Tumour Charity; Medical Research Council; CHILDREN with CANCER UK; Australian Lions Childhood Cancer Research Foundation; Cure Brain Cancer Foundation; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; National Cancer Institute; Ira Sohn Research Conference Foundation; Making Headway Foundation; National Institutes of Health; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology; Marie-Josée and Henry R. Kravis Center for Molecular Oncology; American Lebanese Syrian Associated Charities; Lions Clubs International Foundation; Friedberg Charitable Foundation; Cancer Research UK; Children's Hospital Foundation","keywords":"Gene; Biology; Glioma; Cancer research; Oncology; Bioinformatics; Genetics; Medicine; Computational biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003128946,0.0001747678,0.0002023049,0.0003066661,0.0001510586,0.0003174915,0.0001220639,0.0003218963,0.0008795824],"category_scores_gemma":[0.0007033669,0.00005235652,0.0001013059,0.0003598274,0.000224055,0.0002359704,0.0002465836,0.0003967667,0.0003101495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003171424,"about_ca_system_score_gemma":0.0002347178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001099318,"about_ca_topic_score_gemma":0.003487639,"domain_scores_codex":[0.9998425,0.00002676879,0.00001282567,0.00002899248,0.00005005631,0.00003873581],"domain_scores_gemma":[0.9996601,0.00006946712,0.0001229403,0.00002082381,0.00005673408,0.00006988222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009227212,0.00004231204,0.7632479,0.0001904815,0.00007601083,0.0231762,0.0004091233,0.0005553574,0.03563662,0.001393598,0.01421479,0.1601349],"study_design_scores_gemma":[0.00002859147,0.0002625249,0.8506891,0.0002193295,0.0001252699,0.1087289,0.0007808523,0.0009065961,0.01338878,0.002487235,0.0223377,0.00004531325],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766507,0.00870081,0.002790819,0.002523482,0.0001067563,0.00003656995,0.0009556377,0.0001204896,0.008114787],"genre_scores_gemma":[0.9938586,0.002869796,0.001142429,0.0003602273,0.0001309919,0.00001427056,0.0006676036,0.00002420675,0.0009317753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001099318,"threshold_uncertainty_score":0.002942502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02362995440538189,"score_gpt":0.2565559089169627,"score_spread":0.2329259545115808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}