{"id":"W3014852378","doi":"10.2196/17117","title":"Efficacy and Safety of Rituximab in Refractory CIDP With or Without IgG4 Autoantibodies (RECIPE): Protocol for a Double-Blind, Randomized, Placebo-Controlled Clinical Trial","year":2020,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Peripheral Neuropathies and Disorders","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Chiba University; National Defense Medical College; Japan Agency for Medical Research and Development","keywords":"Medicine; Rituximab; Internal medicine; Multifocal motor neuropathy; Polyradiculoneuropathy; Chronic inflammatory demyelinating polyneuropathy; Placebo; Cohort; Refractory (planetary science); Randomized controlled trial; Clinical endpoint; Clinical trial; Autoantibody; Antibody; Immunology; Pathology; Guillain-Barre syndrome; Mismatch negativity; Lymphoma","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005756191,0.0003611731,0.002745033,0.0002471557,0.0001553897,0.00008258922,0.0002890402,0.0002655281,0.0001521057],"category_scores_gemma":[0.004481186,0.0002066818,0.0003220914,0.0005217975,0.001035531,0.0001819851,0.0001862866,0.001160846,0.00000617759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000491283,"about_ca_system_score_gemma":0.0011465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003375906,"about_ca_topic_score_gemma":0.00008704235,"domain_scores_codex":[0.9940774,0.001651195,0.001730869,0.0008144563,0.001007837,0.0007182093],"domain_scores_gemma":[0.9951402,0.002999942,0.0004214993,0.0004807374,0.0004990672,0.0004585423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.985674,0.004996374,0.0006178434,0.002354288,0.0001503008,0.00005917353,0.0004849,0.000002519639,0.0001579234,0.00008493918,0.001832898,0.003584874],"study_design_scores_gemma":[0.9093788,0.03149218,0.00009140218,0.002242605,0.00002606339,0.000006683644,0.0001685764,0.0009795061,0.0001006953,0.00003059718,0.05526863,0.0002142085],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.01239953,0.00000468982,0.00008849643,0.001663881,0.000007727727,0.9846114,0.00001011859,0.00007142724,0.001142711],"genre_scores_gemma":[0.007181494,0.00000470339,0.0009741316,0.0002142567,0.0003106125,0.9906407,0.00000658439,0.00006822025,0.0005993004],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.07629511,"threshold_uncertainty_score":0.8428239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3531484025439489,"score_gpt":0.5751329632100343,"score_spread":0.2219845606660854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}