{"id":"W3014855480","doi":"10.1016/j.healun.2020.01.1281","title":"Are Two Tests Better Than One? Combining Donor Derived Cell-Free DNA and Gene Expression Profiling for Non-Invasive Surveillance after Heart Transplantation","year":2020,"lang":"en","type":"article","venue":"The Journal of Heart and Lung Transplantation","topic":"Transplantation: Methods and Outcomes","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Ted Rogers Centre for Heart Research; University Health Network","funders":"","keywords":"Medicine; Cohort; Cell-free fetal DNA; Internal medicine; Gold standard (test); Oncology; Transplantation; Retrospective cohort study; Biopsy; Gene expression profiling; Heart transplantation; Gene expression; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01690415,0.001138517,0.004613435,0.002032641,0.0005633179,0.006312028,0.001287927,0.002383064,0.001296547],"category_scores_gemma":[0.02303851,0.0007742646,0.001185425,0.001789756,0.001634525,0.003332505,0.00130145,0.002908016,0.0007678731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006540633,"about_ca_system_score_gemma":0.0009657843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006870895,"about_ca_topic_score_gemma":0.002258728,"domain_scores_codex":[0.9887165,0.004927675,0.000928507,0.001939541,0.002755828,0.0007319893],"domain_scores_gemma":[0.9807588,0.01274142,0.002095474,0.001273716,0.002483827,0.0006466788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005230698,0.0007097621,0.7156892,0.001083147,0.002323839,0.0007485055,0.0007720934,0.001574481,0.04038797,0.001952427,0.005719379,0.2238084],"study_design_scores_gemma":[0.0004723904,0.006261398,0.8197788,0.001715247,0.004934305,0.005629882,0.004120058,0.02270218,0.07646725,0.02098345,0.03622334,0.0007116999],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7712908,0.07732009,0.1118536,0.0192559,0.005193948,0.0004659434,0.00329612,0.00103084,0.01029279],"genre_scores_gemma":[0.930014,0.008200216,0.04715367,0.00757075,0.002495811,0.0003522679,0.001324195,0.0001988282,0.002690311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01690415,"threshold_uncertainty_score":0.08939874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02585864068278275,"score_gpt":0.2920933005804778,"score_spread":0.266234659897695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}