{"id":"W3014873726","doi":"10.1097/tp.0000000000003247","title":"CD38 Antibody Daratumumab for the Treatment of Chronic Active Antibody-mediated Kidney Allograft Rejection","year":2020,"lang":"en","type":"article","venue":"Transplantation","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Metabolomics Innovation Centre; University of Alberta","funders":"","keywords":"Daratumumab; Medicine; Bone marrow; Immunology; Antibody; Transplantation; Immune system; CD38; Antigen; Monoclonal antibody; Internal medicine; Stem cell; Biology; CD34","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003928594,0.0001968779,0.000316081,0.00006658422,0.0001272429,0.00001165256,0.0000540946,0.00008193962,0.00006381697],"category_scores_gemma":[0.00001208018,0.000126352,0.0002172499,0.0002379385,0.00005569019,0.0001060796,0.000001002518,0.00006222521,0.00001756098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000868987,"about_ca_system_score_gemma":0.000120635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001091819,"about_ca_topic_score_gemma":0.00002941012,"domain_scores_codex":[0.9989895,0.00003493346,0.0003137603,0.0002586589,0.0002134371,0.0001897294],"domain_scores_gemma":[0.9992771,0.0002245613,0.0001286179,0.0001349452,0.00009129228,0.0001434671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02303764,0.002373985,0.03497002,0.004439179,0.004055834,0.0001996343,0.01644844,0.000607143,0.8855115,0.0005889543,0.0001320315,0.02763569],"study_design_scores_gemma":[0.0590697,0.0202383,0.3456309,0.001032768,0.007781649,0.0002172346,0.0005865684,0.01441185,0.5351573,0.0000581582,0.01519881,0.0006167557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8220087,0.001472215,0.1526649,0.01010516,0.0008485122,0.007198048,0.003627055,0.0003361235,0.001739212],"genre_scores_gemma":[0.9821432,0.009710161,0.0004877523,0.0002949423,0.0001613193,0.00008992995,0.006990017,0.00002701178,0.00009566099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3503541,"threshold_uncertainty_score":0.5152486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02785295366675163,"score_gpt":0.333094855107289,"score_spread":0.3052419014405374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}