{"id":"W3014873726","doi":"10.1097/tp.0000000000003247","title":"CD38 Antibody Daratumumab for the Treatment of Chronic Active Antibody-mediated Kidney Allograft Rejection","year":2020,"lang":"en","type":"article","venue":"Transplantation","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Metabolomics Innovation Centre; University of Alberta","funders":"","keywords":"Daratumumab; Medicine; Bone marrow; Immunology; Antibody; Transplantation; Immune system; CD38; Antigen; Monoclonal antibody; Internal medicine; Stem cell; Biology; CD34","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002229569,0.0003307113,0.0003319251,0.0001864863,0.0001868818,0.0001772188,0.0002204205,0.0002841506,0.0006811452],"category_scores_gemma":[0.0001456642,0.00005085107,0.0003040707,0.0001077271,0.0001166765,0.0001140853,0.0001276591,0.000513174,0.0002468746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002820803,"about_ca_system_score_gemma":0.0001850679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002424893,"about_ca_topic_score_gemma":0.0005966802,"domain_scores_codex":[0.9999242,0.0000171626,0.00001102872,0.000009117666,0.00001957764,0.00001893649],"domain_scores_gemma":[0.9999408,0.00001235065,0.00001842134,0.000003662734,0.000009446157,0.00001537905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.007012346,0.001230314,0.02402193,0.001467688,0.0005145274,0.02298824,0.0001872163,0.001049701,0.1937687,0.001264537,0.009551403,0.7369433],"study_design_scores_gemma":[0.01318046,0.03414852,0.1536558,0.0008413296,0.001762895,0.2796003,0.0002494234,0.01158248,0.1626843,0.002139688,0.3400539,0.0001007985],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8524412,0.130359,0.004116137,0.003799268,0.0004979745,0.0002258288,0.0001340528,0.000198425,0.008228075],"genre_scores_gemma":[0.9789989,0.01559795,0.00223755,0.00100859,0.0002478846,0.00005700818,0.0001507252,0.000008624497,0.001692772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006811452,"threshold_uncertainty_score":0.002278626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02785295366675163,"score_gpt":0.333094855107289,"score_spread":0.3052419014405374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}