{"id":"W3014887170","doi":"10.1016/j.molbiopara.2020.111276","title":"Isolation and characterization of a novel member of the ACC ligand-gated chloride channel family, Hco-LCG-46, from the parasitic nematode Haemonchus contortus","year":2020,"lang":"en","type":"article","venue":"Molecular and Biochemical Parasitology","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Tech University","funders":"National Institute of Neurological Disorders and Stroke; Natural Sciences and Engineering Research Council of Canada","keywords":"Homomeric; Haemonchus contortus; Biology; Cholinergic; Ligand-gated ion channel; Xenopus; Receptor; Acetylcholine receptor; Protein subunit; Chloride channel; Biochemistry; Molecular biology; Ion channel; Nematode; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006759224,0.000192712,0.0002994105,0.0001924542,0.0002090879,0.0002555204,0.0001499264,0.0003169454,0.000816092],"category_scores_gemma":[0.000260869,0.00009073921,0.0002243242,0.0001832757,0.0001465481,0.0002658044,0.0001628643,0.0003075964,0.0004261098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001722507,"about_ca_system_score_gemma":0.0003176553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001324888,"about_ca_topic_score_gemma":0.001259668,"domain_scores_codex":[0.999947,0.000005508005,0.000005183587,0.00001308259,0.00001514507,0.00001416815],"domain_scores_gemma":[0.9998547,0.00002820192,0.00002720815,0.00001427045,0.00002313684,0.00005251846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001106517,0.00001795539,0.0007065503,0.00003125276,0.0000046422,0.0003047485,0.00004067787,0.00004401461,0.9968711,0.00005536804,0.00006704537,0.001746056],"study_design_scores_gemma":[0.0001183933,0.001014636,0.1529756,0.00004426548,0.00009294495,0.009430478,0.0003318661,0.005581438,0.8037889,0.0003820231,0.02618238,0.000056979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932358,0.001164333,0.003383053,0.0003184981,0.00005139675,0.00004024555,0.0009829751,0.00004978761,0.0007740164],"genre_scores_gemma":[0.9835613,0.001223319,0.006003914,0.0002538165,0.00005162481,0.00002913257,0.005518322,0.00002440743,0.003334177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001324888,"threshold_uncertainty_score":0.002730131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02807645236685638,"score_gpt":0.2882357450116504,"score_spread":0.2601592926447941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}