{"id":"W3014887170","doi":"10.1016/j.molbiopara.2020.111276","title":"Isolation and characterization of a novel member of the ACC ligand-gated chloride channel family, Hco-LCG-46, from the parasitic nematode Haemonchus contortus","year":2020,"lang":"en","type":"article","venue":"Molecular and Biochemical Parasitology","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Tech University","funders":"National Institute of Neurological Disorders and Stroke; Natural Sciences and Engineering Research Council of Canada","keywords":"Homomeric; Haemonchus contortus; Biology; Cholinergic; Ligand-gated ion channel; Xenopus; Receptor; Acetylcholine receptor; Protein subunit; Chloride channel; Biochemistry; Molecular biology; Ion channel; Nematode; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002879285,0.0001386816,0.0003254166,0.0000155797,0.000038618,0.000007890323,0.00006902613,0.000105399,0.00000377837],"category_scores_gemma":[0.000158342,0.00008497953,0.00007507254,0.0001251607,0.000197226,0.00002685923,0.00004405233,0.0001055595,4.094028e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004156587,"about_ca_system_score_gemma":0.00003235331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004706962,"about_ca_topic_score_gemma":0.000002008908,"domain_scores_codex":[0.999205,0.00004984704,0.0002637499,0.0002477577,0.0001182608,0.0001154173],"domain_scores_gemma":[0.9994429,0.00009322077,0.0001259963,0.0001623285,0.00008296218,0.00009254104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000440165,0.0000877883,0.02424411,0.00004540537,0.00006777367,0.000009528711,0.0002455979,0.000001696126,0.9747468,0.00002986089,0.00003610817,0.00004514807],"study_design_scores_gemma":[0.001075978,0.00007700834,0.1863521,0.00004526107,0.0001866039,0.00002159804,0.00003016042,0.001397647,0.810714,0.00001382855,0.0000186949,0.00006712608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952292,0.0005307254,0.001021461,0.002741853,0.00005276643,0.0003122804,0.00008195429,0.00001058518,0.00001917373],"genre_scores_gemma":[0.996323,0.00006283602,0.00001931998,0.003328659,0.00008548113,0.000008333619,0.0001585798,0.00001066893,0.000003084622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1640328,"threshold_uncertainty_score":0.3465365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02807645236685638,"score_gpt":0.2882357450116504,"score_spread":0.2601592926447941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}