{"id":"W3014953259","doi":"10.1128/msphere.00195-20","title":"Identification of the Neuroinvasive Pathogen Host Target, LamR, as an Endothelial Receptor for the Treponema pallidum Adhesin Tp0751","year":2020,"lang":"en","type":"article","venue":"mSphere","topic":"Syphilis Diagnosis and Treatment","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Michael Smith Health Research BC; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Treponema; Bacterial adhesin; Microbiology; Biology; Neisseria; Pathogen; Neisseria meningitidis; Virology; Neisseria gonorrhoeae; Haemophilus influenzae; Syphilis; Streptococcus pneumoniae; Human pathogen; Immunology; Virulence; Bacteria; Gene; Antibiotics; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001276405,0.0001400134,0.0001114618,0.0001469719,0.0001340239,0.0003208564,0.0001809232,0.0004361984,0.001590835],"category_scores_gemma":[0.0001570825,0.00006384308,0.0001483177,0.00005545132,0.000130859,0.0001591734,0.0001857714,0.0003485255,0.0004692685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001684446,"about_ca_system_score_gemma":0.000115711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004667128,"about_ca_topic_score_gemma":0.0005132896,"domain_scores_codex":[0.999909,0.00002253485,0.000002822448,0.00001271428,0.00002604977,0.00002668073],"domain_scores_gemma":[0.9999468,0.00001120004,0.0000121561,0.000006325754,0.00001170605,0.00001175642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001079785,0.00003594402,0.00235653,0.00004252194,0.000007530526,0.0007042157,0.00005059646,0.00008471293,0.9894638,0.0005401098,0.0002297739,0.006376339],"study_design_scores_gemma":[0.00003531003,0.001239598,0.1041162,0.00006548625,0.00005511114,0.0104327,0.0004563115,0.007616777,0.8565293,0.000493795,0.01893504,0.00002441385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862066,0.003234519,0.003758619,0.0005164667,0.00003100408,0.00002732025,0.00008812368,0.00003501612,0.006102295],"genre_scores_gemma":[0.9942335,0.0008914839,0.002055763,0.0001626163,0.00001265636,0.000007523997,0.0001102423,0.000002786514,0.002523293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001590835,"threshold_uncertainty_score":0.00532192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03198487012291631,"score_gpt":0.2737969319247249,"score_spread":0.2418120618018086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}