{"id":"W3014953259","doi":"10.1128/msphere.00195-20","title":"Identification of the Neuroinvasive Pathogen Host Target, LamR, as an Endothelial Receptor for the Treponema pallidum Adhesin Tp0751","year":2020,"lang":"en","type":"article","venue":"mSphere","topic":"Syphilis Diagnosis and Treatment","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Michael Smith Health Research BC; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Treponema; Bacterial adhesin; Microbiology; Biology; Neisseria; Pathogen; Neisseria meningitidis; Virology; Neisseria gonorrhoeae; Haemophilus influenzae; Syphilis; Streptococcus pneumoniae; Human pathogen; Immunology; Virulence; Bacteria; Gene; Antibiotics; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001224248,0.0001412783,0.0002159749,0.000008111907,0.000128699,0.00002625861,0.0001891181,0.00005851522,0.000454829],"category_scores_gemma":[0.0004418369,0.00007654846,0.0001812184,0.000135223,0.00006530496,0.00004193736,0.00003406711,0.00008317026,0.00005958958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002908793,"about_ca_system_score_gemma":0.00009915522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004970336,"about_ca_topic_score_gemma":0.00009205191,"domain_scores_codex":[0.9989539,0.00008042299,0.0002781827,0.0002875353,0.0002452034,0.0001547143],"domain_scores_gemma":[0.9989576,0.000229469,0.0001475879,0.0004629254,0.0001080501,0.00009433492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006245282,0.0008626654,0.05592111,0.0001662731,0.0003251475,0.00001776116,0.003452183,0.00002004007,0.9113212,0.001573825,0.01535043,0.01036479],"study_design_scores_gemma":[0.003433316,0.001715347,0.1093754,0.00009412278,0.0006183649,0.00002265669,0.002289205,0.0004978933,0.7428344,0.0002484233,0.138659,0.0002118837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9671422,0.0007411483,0.00007523819,0.02947305,0.0003628974,0.001410878,0.0004487637,0.00004454022,0.0003013349],"genre_scores_gemma":[0.9964241,0.0001287175,0.0002421384,0.00167689,0.0004602732,0.000234631,0.00005453889,0.00003531389,0.0007433904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1684868,"threshold_uncertainty_score":0.4980058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03198487012291631,"score_gpt":0.2737969319247249,"score_spread":0.2418120618018086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}