{"id":"W3014971121","doi":"10.1038/s41598-020-62630-7","title":"In vivo biodistribution analysis of transmission competent and defective RNA virus-based episomal vector","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Memorial University of Newfoundland; Japan Agency for Medical Research and Development","keywords":"Transgene; Biology; In vivo; Tropism; Gene delivery; Biodistribution; Transduction (biophysics); Viral vector; Gene expression; Virology; Genetic enhancement; Virus; Molecular biology; Neutralizing antibody; Gene; Recombinant DNA; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002319118,0.0002799594,0.0001759693,0.0002318247,0.00007475913,0.0001954437,0.0001572694,0.0002496585,0.0005037027],"category_scores_gemma":[0.0001099937,0.0001197887,0.000175766,0.0001203003,0.0001641122,0.0001984412,0.00007625903,0.0003808255,0.0001535346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001846269,"about_ca_system_score_gemma":0.0002227413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009360135,"about_ca_topic_score_gemma":0.0005931836,"domain_scores_codex":[0.999899,0.00001776662,0.000006823645,0.00002919444,0.00002214153,0.00002505724],"domain_scores_gemma":[0.9998972,0.00001652501,0.00003477815,0.000009413498,0.00002308302,0.00001888858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004113778,0.00001699436,0.00008048098,0.0000105293,0.000002104207,0.00001701181,0.00001021948,0.00001898182,0.9994162,0.00002879186,0.000006875698,0.0003507023],"study_design_scores_gemma":[0.000007581393,0.0006273604,0.001942916,0.000003196331,0.00001590686,0.0001800345,0.0000186674,0.0007854603,0.9959764,0.00001948211,0.0004189243,0.000004075087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929553,0.000633957,0.005531689,0.00003204181,0.000009705765,0.00002488562,0.0001999865,0.00004853591,0.0005639361],"genre_scores_gemma":[0.9892448,0.0009867006,0.006539306,0.00003576566,0.000005578073,0.00005299703,0.0006079527,0.00003869562,0.002488293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009360135,"threshold_uncertainty_score":0.001861155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01601256494466838,"score_gpt":0.2794906176421368,"score_spread":0.2634780526974684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}