{"id":"W3015025685","doi":"10.1016/j.molmed.2020.03.003","title":"Blocking Signalopathic Events to Treat Cerebral Cavernous Malformations","year":2020,"lang":"en","type":"review","venue":"Trends in Molecular Medicine","topic":"Vascular Malformations Diagnosis and Treatment","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Institut National de la Santé et de la Recherche Médicale; Deutsche Forschungsgemeinschaft; Canadian Institutes of Health Research; European Commission","keywords":"Angiogenesis; Biology; Vasculogenesis; Endothelium; Vascular endothelial growth factor; Hypoxia (environmental); Cancer research; Progenitor cell; Cell biology; Pathology; Medicine; Endocrinology; Chemistry; Stem cell; VEGF receptors","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003988728,0.0009418313,0.001472346,0.001490259,0.0001888399,0.0007099839,0.0007664158,0.0008688726,0.005585895],"category_scores_gemma":[0.0006540056,0.0002301521,0.0005944241,0.0009488658,0.0003474276,0.0006885458,0.0004231129,0.002192103,0.001785703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003671338,"about_ca_system_score_gemma":0.0007313273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007202359,"about_ca_topic_score_gemma":0.002003701,"domain_scores_codex":[0.9998801,0.0000203402,0.00002065158,0.00002234436,0.00003781488,0.00001887382],"domain_scores_gemma":[0.9998118,0.00009744349,0.00003652612,0.000005787462,0.00003089584,0.00001763884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002341554,0.0001751871,0.0001190215,0.01811737,0.0001935174,0.0002331069,0.00003250121,0.0003568998,0.00262982,0.002123687,0.024958,0.9508267],"study_design_scores_gemma":[0.0003767152,0.0005341431,0.001203992,0.006127342,0.0009444942,0.001869314,0.00004332206,0.0002928712,0.001941829,0.002413696,0.9842091,0.00004318644],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002961132,0.9973567,0.0002712386,0.0002240686,0.0002795246,0.00001406873,0.00003195236,0.00001938915,0.001507012],"genre_scores_gemma":[0.001995437,0.9959232,0.0003549493,0.000436489,0.0002735928,0.00001801882,0.00005988325,0.000003637401,0.0009348812],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005585895,"threshold_uncertainty_score":0.01868671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0514032378975265,"score_gpt":0.3658176902973886,"score_spread":0.3144144523998622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}