{"id":"W3015035753","doi":"10.1016/j.jaip.2020.03.022","title":"Omalizumab Re-Treatment and Step-Up in Patients with Chronic Spontaneous Urticaria: OPTIMA Trial","year":2020,"lang":"en","type":"article","venue":"The Journal of Allergy and Clinical Immunology In Practice","topic":"Urticaria and Related Conditions","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"Novartis (Canada); Queen's University; Ottawa Allergy Research Corporation; University of Ottawa; Probity Medical Research; Memorial University of Newfoundland; Centre hospitalier de l'Université Laval; Lynde Centre for Dermatology; University of Toronto","funders":"Novartis Pharmaceuticals Canada","keywords":"Medicine; Omalizumab; Dosing; Clinical endpoint; Randomized controlled trial; Internal medicine; Clinical trial; Surgery; Immunoglobulin E; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004029695,0.0001194883,0.0004130706,0.00005297468,0.00005861434,0.0000109059,0.00008166901,0.0002176324,0.0000558717],"category_scores_gemma":[0.000900034,0.00006565906,0.00005197788,0.0001180647,0.0003054127,0.0001508721,0.00004407167,0.0009894629,0.000005166239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007649617,"about_ca_system_score_gemma":0.0002372452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005232701,"about_ca_topic_score_gemma":0.00009556075,"domain_scores_codex":[0.9982997,0.000570683,0.0007088818,0.0001344,0.0001162969,0.0001700374],"domain_scores_gemma":[0.9976264,0.001671516,0.0003515496,0.0001406415,0.0001064096,0.0001035122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9171888,0.004837228,0.0103976,0.000004773318,0.03922848,0.004843035,0.002894255,0.00007469377,0.0001020685,0.001082439,0.0001394012,0.01920728],"study_design_scores_gemma":[0.4587762,0.1482577,0.3496772,0.0003276963,0.02308446,0.007399031,0.003995783,0.0006383068,0.00001989449,0.000201535,0.007269423,0.0003526843],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782658,0.002361864,0.0000298388,0.01845831,0.000259415,0.0002919751,0.000001042661,0.000005019416,0.0003267674],"genre_scores_gemma":[0.9809186,0.01786654,0.0003289144,0.000677119,0.0001374974,0.000002954386,0.000002619646,0.00001070862,0.00005501926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4584125,"threshold_uncertainty_score":0.4298779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02191510144459533,"score_gpt":0.3183907006324672,"score_spread":0.2964755991878719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}