{"id":"W3015049727","doi":"10.1016/j.celrep.2020.03.039","title":"Loss of Thymine DNA Glycosylase Causes Dysregulation of Bile Acid Homeostasis and Hepatocellular Carcinoma","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; London Health Sciences Centre; Lawson Health Research Institute; Cancer Care Ontario; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Farnesoid X receptor; Bile acid; Biology; Nuclear receptor; Cancer research; Small heterodimer partner; Glucose homeostasis; Homeostasis; Coactivator; Epigenetics; Cell biology; Endocrinology; Transcription factor; Biochemistry; Gene; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001330268,0.0003479356,0.0003061033,0.0005573836,0.000164297,0.0002565442,0.0001861707,0.0003604472,0.001752543],"category_scores_gemma":[0.0001420525,0.0002528939,0.0002754107,0.0002280037,0.0003508061,0.0001473425,0.0002708916,0.0005737238,0.0002651132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002546303,"about_ca_system_score_gemma":0.0002248659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006145347,"about_ca_topic_score_gemma":0.0009299531,"domain_scores_codex":[0.9997748,0.00003888278,0.00002874028,0.00004759023,0.00005205563,0.00005795783],"domain_scores_gemma":[0.9997206,0.00003282767,0.00009003737,0.00002430475,0.00001257834,0.0001196643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002517634,0.00006198692,0.0006588763,0.00001400964,0.00001083386,0.0002476048,0.00001667148,0.00006331181,0.9977328,0.0001185377,0.00002677326,0.0007967965],"study_design_scores_gemma":[0.00005119227,0.0008638931,0.01990142,0.000006051817,0.00004413096,0.002099304,0.00008078699,0.001122405,0.9744048,0.00009675347,0.001317878,0.00001138883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980102,0.0002865206,0.001022957,0.00004682962,0.00001850527,0.00001209553,0.0001530017,0.00007030823,0.0003795741],"genre_scores_gemma":[0.9979495,0.0001936187,0.0004219424,0.0000226525,0.000004971867,0.00001316614,0.0001817402,0.00002156698,0.001190884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001752543,"threshold_uncertainty_score":0.005862892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01499767878810175,"score_gpt":0.2148589874135173,"score_spread":0.1998613086254156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}