{"id":"W3015051583","doi":"10.4049/jimmunol.1901440","title":"Secretome-Mediated Interactions with Intestinal Epithelial Cells: A Role for Secretome Components from <i>Lactobacillus rhamnosus</i> R0011 in the Attenuation of <i>Salmonella enterica</i> Serovar Typhimurium Secretome and TNF-α–Induced Proinflammatory Responses","year":2020,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Macrophage Migration Inhibitory Factor","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Proinflammatory cytokine; Biology; Lactobacillus rhamnosus; Salmonella enterica; Innate immune system; Chemokine; Tumor necrosis factor alpha; Cell biology; Microbiology; Immune system; Cytokine; Lactobacillus; Inflammation; Immunology; Salmonella; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001692596,0.0004115288,0.0003366738,0.000134552,0.0001110895,0.0003620436,0.0001315569,0.0002183888,0.001035251],"category_scores_gemma":[0.0001497688,0.000114095,0.0004049425,0.0000998188,0.0001954845,0.0001904567,0.0002940051,0.0004899108,0.0003223588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002070681,"about_ca_system_score_gemma":0.0001953971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003778468,"about_ca_topic_score_gemma":0.0004501939,"domain_scores_codex":[0.9998726,0.00003022091,0.00001174442,0.00001899255,0.00003433874,0.00003210888],"domain_scores_gemma":[0.9998543,0.00001699595,0.00005510398,0.0000139665,0.00001766814,0.0000419253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001244622,0.0000136376,0.0001825021,0.00002774625,0.000003817142,0.00002013123,0.000005147112,0.00001816254,0.9991686,0.000009457045,0.00001181837,0.0004144101],"study_design_scores_gemma":[0.0000258942,0.0004263619,0.02065854,0.00001112957,0.00002230836,0.0001848195,0.00007174904,0.0005993737,0.9765514,0.00002463686,0.00141724,0.000006492543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995322,0.001482166,0.001569906,0.0002209623,0.00002536438,0.00002830052,0.000482112,0.00005091146,0.0008181644],"genre_scores_gemma":[0.9956875,0.000592544,0.001670222,0.0001415135,0.0000123122,0.00002892359,0.0007402249,0.00001624781,0.001110368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001035251,"threshold_uncertainty_score":0.003463209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02178390646605188,"score_gpt":0.2326312809118776,"score_spread":0.2108473744458257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}