{"id":"W3015154527","doi":"10.1038/s41571-020-0352-8","title":"Moving towards personalized treatments of immune-related adverse events","year":2020,"lang":"en","type":"review","venue":"Nature Reviews Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":345,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; McGill University","funders":"","keywords":"Adverse effect; Immune system; Medicine; Intensive care medicine; Cancer; Personalized medicine; Bioinformatics; Immunotherapy; Immunology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001378401,0.0009480832,0.00216618,0.001561557,0.0001915277,0.001216985,0.001022425,0.001463117,0.005095349],"category_scores_gemma":[0.002479362,0.0002603098,0.001002944,0.001213878,0.0003778869,0.001354905,0.00082579,0.002858178,0.001815069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006693457,"about_ca_system_score_gemma":0.00122407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008402586,"about_ca_topic_score_gemma":0.002319591,"domain_scores_codex":[0.9995574,0.0001267087,0.00006179036,0.00006362509,0.0001505309,0.00003989448],"domain_scores_gemma":[0.9984894,0.001017795,0.0001615326,0.00002714655,0.0002432305,0.00006095568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000774312,0.00003815234,0.0001271916,0.01057675,0.0001592219,0.00006186414,0.00001675316,0.0003191076,0.0004682458,0.002676824,0.02469896,0.9607795],"study_design_scores_gemma":[0.0001380996,0.0001805697,0.001223827,0.01533698,0.000559116,0.0007336867,0.0000449835,0.0002969778,0.0002896127,0.005719481,0.975444,0.0000325189],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004587057,0.9982367,0.0001819036,0.0006165792,0.0003038678,0.000004372964,0.00001500091,0.000007692393,0.0005880324],"genre_scores_gemma":[0.0005686466,0.9970585,0.0003137292,0.001114204,0.0005132121,0.000008344358,0.00003710445,0.000002118076,0.000384156],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005095349,"threshold_uncertainty_score":0.01704568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1277862675738988,"score_gpt":0.5063780017279471,"score_spread":0.3785917341540483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}