{"id":"W3015186548","doi":"10.1016/j.neurobiolaging.2020.03.013","title":"Cerebrospinal fluid neuronal pentraxin receptor as a biomarker of long-term progression of Alzheimer's disease: a 24-month follow-up study","year":2020,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Biomarkers in Disease Mechanisms","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sinai Health System; University Health Network; Mount Sinai Hospital; University of Toronto","funders":"","keywords":"Cerebrospinal fluid; Biomarker; Internal medicine; Dementia; Medicine; Alzheimer's disease; Receptor; Oncology; Disease; Gastroenterology; Endocrinology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002627867,0.000387269,0.0008094261,0.0001809012,0.000112008,0.000005982039,0.0006268505,0.0002308358,0.0009908682],"category_scores_gemma":[0.0001610517,0.0003500921,0.0003271943,0.0003097783,0.0007487747,0.00009071879,0.0004760044,0.0003165527,0.00004940635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001316775,"about_ca_system_score_gemma":0.0001713195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001897425,"about_ca_topic_score_gemma":0.000003244799,"domain_scores_codex":[0.9968696,0.0008555188,0.0008822473,0.0007762698,0.0001140688,0.0005022816],"domain_scores_gemma":[0.9983882,0.00014728,0.0006621717,0.0005222976,0.0001534066,0.0001265979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004138427,0.0009978525,0.1889436,0.0001776028,0.00078675,0.00003081691,0.0004362859,0.000001333344,0.7999706,0.000042175,0.001213119,0.003261463],"study_design_scores_gemma":[0.004660915,0.003726172,0.5196301,0.0002070331,0.000668788,0.00002196181,0.0001823291,0.00001075623,0.4704564,0.00002384175,0.00009690392,0.0003148306],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931345,0.00346183,0.00003550461,0.0005410248,0.001468725,0.001029701,0.0001777973,0.00008096034,0.0000699875],"genre_scores_gemma":[0.9992982,0.00005070936,0.00009512416,0.0002038126,0.00002976151,0.00004010134,0.0001942787,0.00004490302,0.00004317524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3306865,"threshold_uncertainty_score":0.9999223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02905898016913496,"score_gpt":0.2853565418203756,"score_spread":0.2562975616512407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}