{"id":"W3015200961","doi":"10.1093/nar/gkaa222","title":"Effect of 2′-5′/3′-5′ phosphodiester linkage heterogeneity on RNA interference","year":2020,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Industrial Research and Consultancy Centre; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Indian Institute of Technology Bombay","keywords":"Phosphodiester bond; Small interfering RNA; Biology; Sense strand; RNA interference; Sense (electronics); RNA; Trans-acting siRNA; Phosphorylation; Cell biology; DNA; Molecular biology; Biochemistry; Gene; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002943024,0.000419115,0.0002600299,0.00009535143,0.0001173654,0.0002952002,0.0002282883,0.0002967392,0.0008815439],"category_scores_gemma":[0.0002550682,0.0001897151,0.0002770292,0.00009792397,0.0002043617,0.000159286,0.0001947764,0.0003588049,0.0002647084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002100559,"about_ca_system_score_gemma":0.000154751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003001464,"about_ca_topic_score_gemma":0.0005619925,"domain_scores_codex":[0.9997818,0.00007184831,0.00002632817,0.00005426085,0.00003990412,0.00002590575],"domain_scores_gemma":[0.9997321,0.00009678559,0.00009776466,0.00002944054,0.00001597879,0.0000279944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000529813,0.000009858102,0.00004598716,0.00002432353,0.000006138835,0.00002990336,0.000008436119,0.0001516923,0.999065,0.00004083,0.000007055811,0.0005577982],"study_design_scores_gemma":[0.00000712141,0.0002057753,0.0003487246,0.000001355614,0.00001153998,0.0000392477,0.000002847126,0.000313376,0.9984,0.00001049615,0.000655496,0.000004040081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931839,0.0006290465,0.003998313,0.00004182446,0.0000247694,0.00006166124,0.0001388083,0.00007420902,0.001847493],"genre_scores_gemma":[0.9944027,0.0004003374,0.003865258,0.00005335888,0.000006698951,0.00005200009,0.0001784653,0.00003176423,0.001009359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008815439,"threshold_uncertainty_score":0.002949059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04818824772131553,"score_gpt":0.3546061241052922,"score_spread":0.3064178763839767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}