{"id":"W3015207228","doi":"10.1038/s41467-020-15590-5","title":"P2X7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in Rett syndrome mice","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institutes of Health; Conselho Nacional de Desenvolvimento Científico e Tecnológico; York University; U.S. Department of Health and Human Services","keywords":"Rett syndrome; Dendritic spine; MECP2; Neuroscience; Medicine; SPINE (molecular biology); Pathology; Biology; Bioinformatics; Genetics; Phenotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005382681,0.0001044948,0.0001063855,0.00003760354,0.0001228363,0.00001746151,0.0002171215,0.0002561139,0.000005215427],"category_scores_gemma":[0.00003872682,0.0001198428,0.00002849262,0.0001496823,0.0001152955,0.000004143777,0.0002997805,0.0003444543,0.000006347707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009121554,"about_ca_system_score_gemma":0.00003104621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004801115,"about_ca_topic_score_gemma":0.0002442845,"domain_scores_codex":[0.9993311,0.00009146773,0.0001605168,0.0002250796,0.00005797994,0.0001339017],"domain_scores_gemma":[0.9996224,0.000007410053,0.00004626971,0.0002314107,0.00005097119,0.00004154365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00001716058,0.0001271584,0.003923795,0.0000152691,0.000007088142,0.00000793983,0.0003982703,0.000002027627,0.9930379,0.0002888214,0.001274623,0.0008999885],"study_design_scores_gemma":[0.004637391,0.001883147,0.7658459,0.00009927061,0.0001259453,0.0004021363,0.002966017,0.000224199,0.129126,0.0006492858,0.09226603,0.001774715],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891062,0.003599119,0.00001143689,0.006946458,0.00004052394,0.0001508479,0.00004097573,0.0000111165,0.00009326166],"genre_scores_gemma":[0.9941422,0.001089578,0.002231114,0.001608502,0.00001059237,0.00002901483,0.0008614843,0.00001594021,0.00001153753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8639119,"threshold_uncertainty_score":0.4887049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01974968605554319,"score_gpt":0.2794484136534908,"score_spread":0.2596987275979476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}