{"id":"W3015239157","doi":"10.1002/ana.25748","title":"Faster Cortical Thinning and Surface Area Loss in Presymptomatic and Symptomatic <i>C9orf72</i> Repeat Expansion Adult Carriers","year":2020,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Toronto Western Hospital; McGill University Health Centre; Sunnybrook Health Science Centre; Université Laval; Montreal Neurological Institute and Hospital; McGill University","funders":"Medical Research Council; Health Canada; Instituto de Salud Carlos III; Canadian Institutes of Health Research; National Institute for Health and Care Research; Ministry of Health, State of Israel; Weston Brain Institute; Wellcome Trust; Fondation Brain Canada","keywords":"C9orf72; Thinning; Medicine; Trinucleotide repeat expansion; Internal medicine; Biology; Dementia; Disease; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002985166,0.0005461911,0.0003360003,0.0007026641,0.0003002606,0.0003481252,0.0001997368,0.0004263659,0.002736341],"category_scores_gemma":[0.001100839,0.0002128346,0.0002499145,0.0003733209,0.0002961829,0.0002788821,0.0002080413,0.0002561285,0.000211447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000178545,"about_ca_system_score_gemma":0.0001335302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004117036,"about_ca_topic_score_gemma":0.004207571,"domain_scores_codex":[0.999889,0.0000144129,0.00001126291,0.00004690632,0.00002077529,0.00001775836],"domain_scores_gemma":[0.9996004,0.00008120169,0.0001979293,0.00002957039,0.00003523564,0.00005574978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002470514,0.0001195584,0.9480607,0.00004124312,0.0001733128,0.00332669,0.0008541166,0.0003156133,0.03460531,0.00009377876,0.0002490374,0.009690056],"study_design_scores_gemma":[0.000009766988,0.000159824,0.996883,0.000003024916,0.00002831497,0.001772533,0.00008634273,0.0002155422,0.0007194723,0.00004703797,0.00007191544,0.000003105454],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996914,0.00004437647,0.00007245866,0.000005796955,0.000001125964,0.000002480792,0.00007978309,0.000008747342,0.00009404413],"genre_scores_gemma":[0.9994938,0.00002851965,0.0001303749,0.000006236228,0.000002228219,0.000003247864,0.0001517595,0.000004983328,0.0001787183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004117036,"threshold_uncertainty_score":0.009153962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05659560879856003,"score_gpt":0.3134341595826781,"score_spread":0.2568385507841181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}