{"id":"W3015256595","doi":"10.1371/journal.pgen.1008733","title":"Loss of Cdc13 causes genome instability by a deficiency in replication-dependent telomere capping","year":2020,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Telomere; Homologous chromosome; Chromosome; Homologous recombination; Chromosome instability; DNA replication; Genome instability; Genetics; Telomere-binding protein; DNA; Genome; Chromosome segregation; Molecular biology; DNA-binding protein; Gene; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001290423,0.0001425467,0.0001798735,0.00002753536,0.00002845568,0.000009468148,0.0002990527,0.000125925,0.00002368599],"category_scores_gemma":[0.0001863572,0.0001553047,0.00005338341,0.0001636081,0.00007032783,0.000002635542,0.0001952649,0.00008618629,0.00000814882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002558812,"about_ca_system_score_gemma":0.00009509376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007880943,"about_ca_topic_score_gemma":0.00002771678,"domain_scores_codex":[0.9986227,0.00005612076,0.0003626412,0.000540039,0.0001972572,0.0002212211],"domain_scores_gemma":[0.9990281,0.00001019077,0.0001193235,0.0006477057,0.00009563293,0.00009900438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000206506,0.0001502864,0.0132034,0.00008286102,0.00001682656,0.000001807985,0.0002668843,0.0001756832,0.9858857,0.00003304838,0.00003527073,0.0001275566],"study_design_scores_gemma":[0.0002775296,0.0002286296,0.001324841,0.000007469093,0.00001387825,0.000002914121,0.0001455472,0.0003855944,0.9961076,0.00008097707,0.001253594,0.0001714135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964991,0.001965976,0.0004564149,0.0001774393,0.0000233742,0.0003241148,0.00008157057,0.00001694171,0.0004550255],"genre_scores_gemma":[0.9984549,0.0002244103,0.0009056207,0.0002297127,0.00004043263,0.00003209517,0.0000612214,0.00002418978,0.00002736587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01187856,"threshold_uncertainty_score":0.6333143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02088220957485502,"score_gpt":0.2416854749171656,"score_spread":0.2208032653423105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}