{"id":"W3015296716","doi":"10.1007/s40291-020-00461-y","title":"Development of a Rapid and Sensitive IDH1/2 Mutation Detection Method for Glial Tumors and a Comparative Mutation Analysis of 236 Glial Tumor Samples","year":2020,"lang":"en","type":"article","venue":"Molecular Diagnosis & Therapy","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Türkiye Bilimsel ve Teknolojik Araştırma Kurumu","keywords":"Sanger sequencing; IDH1; IDH2; Mutation; Isocitrate dehydrogenase; Glial tumor; Glioma; Biology; Mutation testing; Immunohistochemistry; Cancer research; Pathology; Gene; Genetics; Medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001981041,0.0002000169,0.0007019837,0.0002738964,0.00007280289,0.00001614321,0.00002763848,0.00005093162,0.0000102472],"category_scores_gemma":[0.00009733684,0.0001764617,0.0001729466,0.0005392211,0.00006546033,0.00005060919,0.00001570144,0.0000492231,3.008681e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004443759,"about_ca_system_score_gemma":0.00005784246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001045704,"about_ca_topic_score_gemma":0.0000808481,"domain_scores_codex":[0.9986982,0.0001373072,0.0004300904,0.0003607393,0.0002342044,0.0001394227],"domain_scores_gemma":[0.9988928,0.0003603992,0.0002891075,0.00009684578,0.0002496783,0.0001111096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002103088,0.0006754498,0.006724075,0.0001271551,0.005783767,0.00008446974,0.02197855,0.0005306547,0.8023767,0.0001601276,0.00001028753,0.1594457],"study_design_scores_gemma":[0.003733402,0.001253825,0.09636585,0.00005149355,0.001411591,0.00001105007,0.001456712,0.007627125,0.8878089,0.00003492969,0.0001101856,0.0001349297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9450765,0.0007637888,0.05258421,0.0003813912,0.00001663742,0.001085969,0.00007030691,0.0000171785,0.000004059675],"genre_scores_gemma":[0.956421,0.000102764,0.04258962,0.0003228371,0.00001855675,0.0004060555,0.0001240857,0.00001495912,1.885608e-7],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1593107,"threshold_uncertainty_score":0.7195899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05197320421847684,"score_gpt":0.325615170888875,"score_spread":0.2736419666703981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}