{"id":"W3015299299","doi":"10.1136/bmjpo-2020-000651","title":"Fast I(n)dentification of Pathogens in Neonates (FINDPATH-N): protocol for a prospective pilot cohort study of next-generation sequencing for pathogen identification in neonates with suspected sepsis","year":2020,"lang":"en","type":"article","venue":"BMJ Paediatrics Open","topic":"Neonatal and Maternal Infections","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute; McMaster University; McMaster Children's Hospital","funders":"Canadian Institutes of Health Research; Canadian Blood Services; McMaster University","keywords":"Sepsis; Medicine; Neonatal sepsis; Blood culture; Prospective cohort study; Biomarker; Intensive care medicine; Gold standard (test); Cohort; Intensive care; Pathogen; Internal medicine; Immunology; Biology; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008190105,0.0001949762,0.0005108402,0.0003034562,0.00007416851,0.00007231837,0.0002117317,0.00007327161,0.00001180436],"category_scores_gemma":[0.0004792892,0.0001707191,0.00006392296,0.001042416,0.00003217954,0.0003745227,0.0000863733,0.0001197108,0.000001699207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002110585,"about_ca_system_score_gemma":0.0003055289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001128258,"about_ca_topic_score_gemma":0.001700209,"domain_scores_codex":[0.9978696,0.00009123401,0.0009834943,0.0005348222,0.0003160367,0.0002047762],"domain_scores_gemma":[0.9980829,0.0001361062,0.0006354,0.0002682214,0.0007982031,0.00007920712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002806741,0.001470217,0.6678526,0.0008258651,0.00008805616,0.00001224061,0.003076989,0.000744118,0.3211712,0.0002320036,0.00009466743,0.001625316],"study_design_scores_gemma":[0.02012512,0.007548832,0.8430688,0.0002595104,0.0003976471,0.00001893682,0.004562978,0.01758356,0.1051743,0.0006554614,0.0001184813,0.0004863805],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.738247,0.00001084281,0.003183867,0.0002019493,0.00004382301,0.258037,0.0002005358,0.00002480663,0.00005016394],"genre_scores_gemma":[0.7514738,0.000003317788,0.002226216,0.00002432574,0.0000976881,0.2458582,0.0002201782,0.00003064208,0.00006562287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.215997,"threshold_uncertainty_score":0.6961723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1377972216063379,"score_gpt":0.3684110556918528,"score_spread":0.2306138340855149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}