{"id":"W3015326574","doi":"10.1371/journal.ppat.1008498","title":"Intestinal restriction of Salmonella Typhimurium requires caspase-1 and caspase-11 epithelial intrinsic inflammasomes","year":2020,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; CH.I.L.D. Foundation; National Institutes of Health; Crohn's and Colitis Canada","keywords":"Inflammasome; Salmonella enterica; Salmonella; Caspase; Microbiology; Caspase 1; Intracellular; Proinflammatory cytokine; Pyroptosis; Chemistry; Apoptosis; Cell biology; Programmed cell death; Biology; Inflammation; Biochemistry; Bacteria; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008495043,0.0001975145,0.0002230808,0.00006101395,0.00007523926,0.00001658655,0.0001363634,0.0001431323,0.00001933237],"category_scores_gemma":[0.00039658,0.0001948151,0.00008763575,0.0001636723,0.0001357032,0.000009257816,0.0001575035,0.0001098347,0.00001334117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008139161,"about_ca_system_score_gemma":0.00007678088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002675359,"about_ca_topic_score_gemma":0.00002031495,"domain_scores_codex":[0.9988595,0.00007240313,0.000323915,0.0003553779,0.0001429444,0.0002458503],"domain_scores_gemma":[0.9993413,0.00002278711,0.0001461974,0.0002447064,0.000134969,0.0001100142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002109511,0.00005089348,0.02075393,0.00007397186,0.0000574902,0.00003052394,0.0002361674,0.00002597713,0.9758759,0.00008737178,0.0003236283,0.00227323],"study_design_scores_gemma":[0.000934456,0.0008588406,0.02042296,0.00003963609,0.0001050458,0.00003196446,0.0004313841,0.0001402769,0.9727176,0.0001068116,0.003856458,0.0003545345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977505,0.0009122975,0.00008819765,0.000473249,0.00008320678,0.0001931668,0.00007266479,0.00002525779,0.0004014613],"genre_scores_gemma":[0.9982616,0.0006287402,0.000362779,0.0001957873,0.0003218788,0.00001498326,0.0001258422,0.00003105139,0.00005738792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00353283,"threshold_uncertainty_score":0.7944331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01566837595820503,"score_gpt":0.212737096207358,"score_spread":0.197068720249153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}