{"id":"W3015326574","doi":"10.1371/journal.ppat.1008498","title":"Intestinal restriction of Salmonella Typhimurium requires caspase-1 and caspase-11 epithelial intrinsic inflammasomes","year":2020,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; CH.I.L.D. Foundation; National Institutes of Health; Crohn's and Colitis Canada","keywords":"Inflammasome; Salmonella enterica; Salmonella; Caspase; Microbiology; Caspase 1; Intracellular; Proinflammatory cytokine; Pyroptosis; Chemistry; Apoptosis; Cell biology; Programmed cell death; Biology; Inflammation; Biochemistry; Bacteria; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001831365,0.000258491,0.0002230958,0.0001273228,0.00007595726,0.0003201383,0.000102276,0.0002596368,0.0008543528],"category_scores_gemma":[0.0001379942,0.0001302455,0.000274116,0.00008564065,0.0002244151,0.0002986601,0.0001821258,0.0006533384,0.0002487542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002103014,"about_ca_system_score_gemma":0.0001668956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002103735,"about_ca_topic_score_gemma":0.0004421629,"domain_scores_codex":[0.9998184,0.00003519237,0.00001922657,0.00003300448,0.000031672,0.0000625372],"domain_scores_gemma":[0.9998478,0.00002301569,0.00005689831,0.00001643941,0.00002018824,0.00003574824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002809405,0.00002378916,0.0004592301,0.00003780747,0.00000209786,0.00004777348,0.00002223242,0.00003176624,0.9985797,0.00005337585,0.00001010865,0.000451186],"study_design_scores_gemma":[0.00003110711,0.001358066,0.03068337,0.00001869103,0.00001803694,0.0006600586,0.0001808787,0.0008307257,0.9648889,0.000105564,0.001216762,0.000007835333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979029,0.000710626,0.0007180416,0.00006313309,0.00001027732,0.000008073016,0.0001698019,0.0000185647,0.0003987977],"genre_scores_gemma":[0.9977738,0.0004227064,0.0007981135,0.00002828662,0.000003727737,0.00001116886,0.0002398774,0.000005875386,0.0007163993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008543528,"threshold_uncertainty_score":0.002858043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01566837595820503,"score_gpt":0.212737096207358,"score_spread":0.197068720249153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}