{"id":"W3015343921","doi":"10.1089/hum.2020.046","title":"Gene Therapy for Cystic Fibrosis Paved the Way for the Use of Adeno-Associated Virus in Gene Therapy","year":2020,"lang":"en","type":"review","venue":"Human Gene Therapy","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Genetic enhancement; Adeno-associated virus; Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Gene; Gene delivery; Medicine; Virus; Virology; Biology; Genetics; Internal medicine; Vector (molecular biology)","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001497387,0.001208774,0.003664548,0.0003747101,0.0005695071,0.0001847143,0.001488732,0.0005479578,0.0002652555],"category_scores_gemma":[0.0006364532,0.0006475582,0.001922444,0.001055789,0.0005063686,0.0001365409,0.0001186439,0.0008675612,0.00001647485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004671983,"about_ca_system_score_gemma":0.000694887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002391606,"about_ca_topic_score_gemma":0.0001073246,"domain_scores_codex":[0.993727,0.0009014867,0.001875603,0.001181993,0.001085224,0.00122869],"domain_scores_gemma":[0.9903688,0.005854592,0.001181298,0.001860219,0.0004780025,0.0002570933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0038221,0.0007565761,0.00001642936,0.001681299,0.00312271,0.00001969333,0.0008150875,0.00003269503,0.06518935,0.00004945673,0.002907797,0.9215868],"study_design_scores_gemma":[0.008382128,0.004097912,0.0004108282,0.001945209,0.000433691,0.00002844171,0.00003842638,0.0001763203,0.01351882,0.000289796,0.9699951,0.0006833359],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004799811,0.9754335,0.0007178798,0.0004958154,0.0002744925,0.01658982,0.001567327,0.0001140805,0.000007282284],"genre_scores_gemma":[0.000618968,0.986958,0.002705054,0.0007432595,0.0009392731,0.005757137,0.001221886,0.0004481023,0.0006083733],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9670873,"threshold_uncertainty_score":0.9995975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1964319095908336,"score_gpt":0.4016826161247216,"score_spread":0.2052507065338879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}