{"id":"W3015343921","doi":"10.1089/hum.2020.046","title":"Gene Therapy for Cystic Fibrosis Paved the Way for the Use of Adeno-Associated Virus in Gene Therapy","year":2020,"lang":"en","type":"review","venue":"Human Gene Therapy","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Genetic enhancement; Adeno-associated virus; Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Gene; Gene delivery; Medicine; Virus; Virology; Biology; Genetics; Internal medicine; Vector (molecular biology)","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006804337,0.000562582,0.0007730448,0.002201174,0.0002591039,0.0008355986,0.0004812899,0.0009514104,0.004055798],"category_scores_gemma":[0.0007172857,0.0001611125,0.0004891917,0.001683187,0.0006123156,0.001539018,0.0006258237,0.002470035,0.002782648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006022709,"about_ca_system_score_gemma":0.0009075341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005743442,"about_ca_topic_score_gemma":0.00112654,"domain_scores_codex":[0.9997751,0.00004745284,0.00002511583,0.00003286219,0.0001000318,0.00001939252],"domain_scores_gemma":[0.9996343,0.000202994,0.00002778691,0.00001276246,0.0000881175,0.0000341048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004987605,0.00007579904,0.0001057959,0.009048956,0.00004368101,0.0002068857,0.00009253074,0.0002698273,0.003869855,0.01099044,0.04241465,0.9328318],"study_design_scores_gemma":[0.000007221593,0.0000622175,0.0002263387,0.001703646,0.00002985943,0.0007640785,0.00003020861,0.00003253617,0.0004841866,0.002055008,0.9945952,0.000009505959],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008821519,0.9967963,0.0002248158,0.0005514323,0.0005095827,0.000003924976,0.00001127931,0.000009931177,0.001804584],"genre_scores_gemma":[0.0004960919,0.9979066,0.0002702335,0.0002521549,0.0002344252,0.000004032604,0.00001623677,0.00000198605,0.0008183046],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004055798,"threshold_uncertainty_score":0.01356798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1964319095908336,"score_gpt":0.4016826161247216,"score_spread":0.2052507065338879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}