{"id":"W3015347082","doi":"10.1124/jpet.119.263715","title":"Treatment of Allergic Asthma with Fenretinide Formulation (LAU-7b) Downregulates ORMDL Sphingolipid Biosynthesis Regulator 3 (Ormdl3) Expression and Normalizes Ceramide Imbalance","year":2020,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Sphingolipid; Fenretinide; Ceramide; Immunoglobulin E; Immunology; Asthma; Allergy; Internal medicine; Endocrinology; Biology; Medicine; Cell biology; Gene; Biochemistry; Antibody; Retinoid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000172539,0.0003296332,0.0005304387,0.0002926644,0.0002768283,0.0002787351,0.0002678421,0.0003957738,0.002025163],"category_scores_gemma":[0.0001134032,0.0001140358,0.0003983188,0.000137955,0.0002999536,0.0002035168,0.0001876582,0.001174756,0.0005590562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002025274,"about_ca_system_score_gemma":0.0003698873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006301167,"about_ca_topic_score_gemma":0.0009727079,"domain_scores_codex":[0.9998223,0.00003063521,0.00001387574,0.00002515412,0.00005199688,0.00005617219],"domain_scores_gemma":[0.9999429,0.00000564481,0.00001404659,0.000006526853,0.000008243833,0.00002263946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002360529,0.000612337,0.0003078086,0.00007591822,0.00002147642,0.0001486272,0.00002059993,0.00006470016,0.9855067,0.0000811292,0.0002536561,0.01054644],"study_design_scores_gemma":[0.0005866629,0.006794346,0.006869596,0.00002045092,0.0001094035,0.0007780326,0.0001071526,0.0008952736,0.9758974,0.0001068937,0.007818596,0.00001622298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909949,0.004360036,0.00147218,0.0004626595,0.0002117033,0.00009533848,0.0003018821,0.0002559422,0.001845421],"genre_scores_gemma":[0.9935521,0.001571629,0.001656823,0.0001707379,0.00004630781,0.00007722618,0.0003744669,0.0000282703,0.002522478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002025163,"threshold_uncertainty_score":0.006774843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01494586968191406,"score_gpt":0.2772580558897662,"score_spread":0.2623121862078521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}