{"id":"W3015361066","doi":"10.3389/fimmu.2020.00574","title":"Retinal Distribution and Extracellular Activity of Granzyme B: A Serine Protease That Degrades Retinal Pigment Epithelial Tight Junctions and Extracellular Matrix Proteins","year":2020,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"International Collaboration On Repair Discoveries; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Extracellular matrix; Retinal; Granzyme B; Cell biology; Retinal pigment epithelium; Extracellular; Chemistry; Serine protease; Protease; Biology; Biochemistry; Cytotoxic T cell; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000114839,0.0001547156,0.0001126294,0.0009060359,0.0001277175,0.000260933,0.00008608812,0.0002158473,0.001004378],"category_scores_gemma":[0.0001566655,0.00009903404,0.0001857269,0.000347618,0.0001565359,0.0002096199,0.0001600837,0.0002430425,0.0002690643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002036321,"about_ca_system_score_gemma":0.00009944825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001455163,"about_ca_topic_score_gemma":0.000911148,"domain_scores_codex":[0.9999119,0.00001145676,0.00000923244,0.00002765729,0.00001923134,0.00002057473],"domain_scores_gemma":[0.9998965,0.000007255711,0.00004915984,0.000007975188,0.00002102359,0.00001810322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008058517,0.00004023387,0.02762568,0.0001088398,0.00006427742,0.0005278264,0.00014793,0.00002897249,0.9567853,0.0001051562,0.0001394787,0.01362043],"study_design_scores_gemma":[0.00002638031,0.0005789335,0.8150491,0.00002623237,0.00008278304,0.004558677,0.0002380272,0.0002926652,0.1756589,0.0001045556,0.003370069,0.00001371474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926011,0.00510473,0.0007303031,0.00004149355,0.000009827554,0.000009591791,0.0002843276,0.00002389077,0.001194762],"genre_scores_gemma":[0.9962431,0.001704491,0.0006177639,0.00003715109,0.000007372029,0.00001113704,0.0002095723,0.000005856931,0.001163604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001455163,"threshold_uncertainty_score":0.003359973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00887742627979748,"score_gpt":0.2125344082110658,"score_spread":0.2036569819312683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}