{"id":"W3015361066","doi":"10.3389/fimmu.2020.00574","title":"Retinal Distribution and Extracellular Activity of Granzyme B: A Serine Protease That Degrades Retinal Pigment Epithelial Tight Junctions and Extracellular Matrix Proteins","year":2020,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"International Collaboration On Repair Discoveries; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Extracellular matrix; Retinal; Granzyme B; Cell biology; Retinal pigment epithelium; Extracellular; Chemistry; Serine protease; Protease; Biology; Biochemistry; Cytotoxic T cell; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001991469,0.0002205078,0.0002922468,0.00006006075,0.0001016349,0.00001758006,0.0001243226,0.0002183135,0.00001590583],"category_scores_gemma":[0.00009744591,0.0002163563,0.00006127112,0.0001307267,0.0003773014,0.00001508235,0.0001392572,0.0002142997,0.000001080096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002379663,"about_ca_system_score_gemma":0.00007200015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000369084,"about_ca_topic_score_gemma":0.000007708276,"domain_scores_codex":[0.9987265,0.0001601526,0.0002629508,0.0004441236,0.0001193573,0.0002868803],"domain_scores_gemma":[0.9995338,0.00000621915,0.0001590581,0.0001753382,0.00004193301,0.00008360694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002424734,0.0001493054,0.07076619,0.0001604894,0.0001023583,0.00002356282,0.0002060515,0.000004504342,0.9207691,0.000262977,0.0007008554,0.004429849],"study_design_scores_gemma":[0.004808176,0.002484099,0.1240189,0.0001113719,0.0001103798,0.0001184605,0.0009770129,0.0007719133,0.7814491,0.0007393259,0.08356448,0.0008467871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9337578,0.01236269,0.05180009,0.001151987,0.0001845706,0.0006480598,0.00005166085,0.00001442633,0.00002874637],"genre_scores_gemma":[0.9923339,0.001476587,0.00531591,0.000013518,0.00004067276,0.00009061026,0.0001808997,0.00001761457,0.0005302607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.13932,"threshold_uncertainty_score":0.8822753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00887742627979748,"score_gpt":0.2125344082110658,"score_spread":0.2036569819312683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}