{"id":"W3015368151","doi":"10.3389/fimmu.2020.00536","title":"RIPK3 and Caspase-1/11 Are Necessary for Optimal Antigen-Specific CD8 T Cell Response Elicited by Genetically Modified Listeria monocytogenes","year":2020,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Genentech; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo; Yale University","keywords":"Biology; Pyroptosis; Cytotoxic T cell; Antigen; T cell; CD8; Microbiology; Immune system; Immunology; Inflammasome; Inflammation; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000176387,0.0005804023,0.0004217548,0.0001633242,0.0001409333,0.0003380708,0.0002518806,0.0004130172,0.001356455],"category_scores_gemma":[0.0002399601,0.0002356219,0.0003773311,0.0001041332,0.0003915952,0.0002664522,0.0002800518,0.001043288,0.0005368213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003825098,"about_ca_system_score_gemma":0.0004375598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002636716,"about_ca_topic_score_gemma":0.0004062325,"domain_scores_codex":[0.999662,0.00005638096,0.0000629311,0.00005872496,0.00005088613,0.0001090049],"domain_scores_gemma":[0.9996697,0.00003978751,0.0001472133,0.00003062849,0.00002098677,0.00009178925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005449797,0.00005122062,0.0002905717,0.00006085837,0.000007546897,0.00005812681,0.00001221568,0.00012131,0.9979312,0.00005393516,0.00002237414,0.0008457397],"study_design_scores_gemma":[0.0001566558,0.0008946022,0.0106058,0.00002129112,0.00005479817,0.0007448288,0.00005109749,0.001637842,0.9837961,0.0001341957,0.001888595,0.00001411519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970257,0.0007441101,0.001200144,0.00009397996,0.00002322937,0.00002580932,0.0002730221,0.00006979723,0.0005442516],"genre_scores_gemma":[0.9963592,0.0002975345,0.001683158,0.00004970664,0.000008936122,0.00005686608,0.0005060809,0.00002415871,0.001014353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001356455,"threshold_uncertainty_score":0.004537761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01297835847404609,"score_gpt":0.2232733677457569,"score_spread":0.2102950092717108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}