{"id":"W3015448359","doi":"10.1016/j.talanta.2020.121022","title":"Analysis of the role played by ligand-induced folding of the cocaine-binding aptamer in the photochrome aptamer switch assay","year":2020,"lang":"en","type":"article","venue":"Talanta","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada; Ministère de l’Éducation, Gouvernement de l’Ontario; University of Toronto; York University","keywords":"Aptamer; Chemistry; Conjugate; Ligand (biochemistry); Folding (DSP implementation); Fluorescence anisotropy; Conjugated system; Covalent bond; Biophysics; Receptor; Polymer; Biochemistry; Organic chemistry; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003428327,0.000152322,0.0002972072,0.00004990044,0.00007695178,0.00001343653,0.0005215427,0.0001210484,0.0000022949],"category_scores_gemma":[0.0001266364,0.00007703286,0.0003226784,0.0009556755,0.0001012978,0.000003705635,0.0001726889,0.000158429,4.054671e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001103881,"about_ca_system_score_gemma":0.00002775706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001005545,"about_ca_topic_score_gemma":0.0001052425,"domain_scores_codex":[0.9988307,0.0001601722,0.0003112819,0.0002728472,0.0002461897,0.0001788007],"domain_scores_gemma":[0.9991139,0.00004488553,0.0002734216,0.0004927138,0.00004795731,0.00002719377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000306849,0.00003597175,0.01366733,0.000005976855,0.0003110697,5.570657e-7,0.0002223553,0.00001433037,0.9851884,0.000007739767,0.0002326152,0.000283024],"study_design_scores_gemma":[0.0001627004,0.00006028369,0.00269917,0.00002098403,0.0003776766,0.000002408083,0.0005273948,0.0007490779,0.9946259,0.00001009364,0.0006555841,0.0001087422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986436,0.0001088536,0.00006917377,0.0005245091,0.00001940334,0.0002055213,0.00005891701,0.000008691299,0.0003613225],"genre_scores_gemma":[0.9992787,0.0000442299,0.0000375148,0.0004968048,0.00003497633,0.000007466017,0.00004165811,0.00001195039,0.00004672707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01096816,"threshold_uncertainty_score":0.3141309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0107039545239775,"score_gpt":0.2542848546644099,"score_spread":0.2435809001404324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}