{"id":"W3015449027","doi":"10.1016/j.ccell.2020.03.011","title":"Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas","year":2020,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":472,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; SickKids Foundation; Princess Margaret Cancer Centre; Hospital for Sick Children; University of Toronto","funders":"Hospital for Sick Children; Ontario Genomics Institute; National Cancer Institute; Government of Canada; Canadian Institutes of Health Research; Genome Canada; American Lebanese Syrian Associated Charities; St. Jude Children's Research Hospital; Canadian Cancer Society; Pediatric Low Grade Astrocytoma Foundation","keywords":"Cohort; MAPK/ERK pathway; Downregulation and upregulation; Biology; Protein kinase A; Histology; Bioinformatics; Oncology; Cancer research; Medicine; Kinase; Internal medicine; Pathology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004948982,0.0001087338,0.0004476014,0.00009720069,0.00001257575,0.000006420426,0.00004472212,0.00006789123,0.0003532089],"category_scores_gemma":[0.00002926714,0.00008358026,0.0002148414,0.0009379674,0.00003896067,0.00001862869,0.00002460841,0.00008265426,0.000005677289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003438619,"about_ca_system_score_gemma":0.00006164853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003442852,"about_ca_topic_score_gemma":0.00003907424,"domain_scores_codex":[0.999166,0.00003181658,0.0002895701,0.0002578195,0.0001357996,0.0001189582],"domain_scores_gemma":[0.9994014,0.00005352725,0.00009334269,0.0001568405,0.00006722365,0.0002276942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001039521,0.000544906,0.9877251,0.0001350831,0.001414625,0.0002715939,0.0001714573,0.0001167305,0.005305198,0.00001913343,0.001579119,0.002613117],"study_design_scores_gemma":[0.01029282,0.001694,0.7811374,0.00007470529,0.04396461,0.000004920447,0.0003741682,0.01611,0.1381062,0.00001650532,0.00774383,0.0004808326],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866604,0.01158331,0.00005561084,0.0009688945,0.00005171729,0.0001531065,0.00005087681,0.00001921572,0.0004568306],"genre_scores_gemma":[0.9961479,0.002929397,0.0001820594,0.0005816427,0.00008346738,0.00001453806,0.00003406182,0.0000118632,0.00001511035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2065877,"threshold_uncertainty_score":0.386739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02635705817207019,"score_gpt":0.3148346819868627,"score_spread":0.2884776238147925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}