{"id":"W3015449027","doi":"10.1016/j.ccell.2020.03.011","title":"Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas","year":2020,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":472,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; SickKids Foundation; Princess Margaret Cancer Centre; Hospital for Sick Children; University of Toronto","funders":"Hospital for Sick Children; Ontario Genomics Institute; National Cancer Institute; Government of Canada; Canadian Institutes of Health Research; Genome Canada; American Lebanese Syrian Associated Charities; St. Jude Children's Research Hospital; Canadian Cancer Society; Pediatric Low Grade Astrocytoma Foundation","keywords":"Cohort; MAPK/ERK pathway; Downregulation and upregulation; Biology; Protein kinase A; Histology; Bioinformatics; Oncology; Cancer research; Medicine; Kinase; Internal medicine; Pathology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005030783,0.0002773619,0.0004365312,0.0022685,0.0004855206,0.001010562,0.0003962568,0.0003738259,0.0009697325],"category_scores_gemma":[0.001146319,0.0002436639,0.0002654906,0.002081727,0.0002702706,0.0003446371,0.0004576079,0.0003529934,0.0003932168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009644115,"about_ca_system_score_gemma":0.000636348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00668055,"about_ca_topic_score_gemma":0.007605603,"domain_scores_codex":[0.9994622,0.0000529719,0.0000451102,0.0001391015,0.0001893353,0.0001112862],"domain_scores_gemma":[0.99943,0.0001166545,0.0001475715,0.00005272927,0.0001889902,0.00006395924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009764364,0.00006530739,0.905365,0.0001330114,0.0001282442,0.001062851,0.0003672457,0.001043459,0.03607774,0.0004224681,0.00189146,0.05246668],"study_design_scores_gemma":[0.00002322449,0.0001794355,0.9574248,0.00002445418,0.0002283128,0.004616593,0.0006445416,0.001225199,0.01878711,0.0002376506,0.01659546,0.00001329542],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891087,0.002711811,0.001017931,0.0001592404,0.00001433653,0.00004259575,0.004606364,0.00006978893,0.002269228],"genre_scores_gemma":[0.9882598,0.001753719,0.00214326,0.000070912,0.00002306956,0.00004801176,0.006853463,0.00004000118,0.000807741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00668055,"threshold_uncertainty_score":0.01328331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02635705817207019,"score_gpt":0.3148346819868627,"score_spread":0.2884776238147925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}