{"id":"W3015451581","doi":"10.1128/iai.00017-20","title":"Salmonella enterica Infection of Murine and Human Enteroid-Derived Monolayers Elicits Differential Activation of Epithelium-Intrinsic Inflammasomes","year":2020,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; NIH Office of the Director; Canadian Institutes of Health Research; Government of Canada; National Institutes of Health; Crohn's and Colitis Canada; University of Washington","keywords":"Inflammasome; Salmonella enterica; Biology; Salmonella; Microbiology; Caspase 1; Signal transduction; Caspase; Intestinal epithelium; Cell biology; Apoptosis; Epithelium; Immunology; Programmed cell death; Inflammation; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002980914,0.0002986848,0.0002746484,0.000220201,0.0001014793,0.000357289,0.00007911163,0.0002796502,0.00104724],"category_scores_gemma":[0.0001930914,0.0001636607,0.0003117907,0.0001883673,0.0001567849,0.0002190069,0.0002606646,0.0004683493,0.0004632613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001996438,"about_ca_system_score_gemma":0.0001659353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003478779,"about_ca_topic_score_gemma":0.0005364704,"domain_scores_codex":[0.9997117,0.00006727574,0.00004538294,0.00004318263,0.00005319402,0.0000793201],"domain_scores_gemma":[0.9998939,0.00002388789,0.00002360693,0.00001856145,0.00001671736,0.00002337179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000489823,0.00004177284,0.0007424501,0.00005114466,0.000007685197,0.0001093641,0.00003859824,0.00002935775,0.9976227,0.00005733231,0.00004781521,0.0007619027],"study_design_scores_gemma":[0.00008188959,0.002671777,0.03426522,0.0000325904,0.00003827612,0.001821947,0.0003332486,0.0008999862,0.955905,0.00009076869,0.003842205,0.00001707174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939498,0.002640832,0.001267685,0.0001135963,0.00004070332,0.00002708216,0.0005453372,0.000029142,0.001385815],"genre_scores_gemma":[0.99418,0.001605311,0.001528109,0.0001226975,0.00001112997,0.00002929483,0.001324849,0.00001054655,0.001188167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00104724,"threshold_uncertainty_score":0.003503442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0112143152957036,"score_gpt":0.2347398322988438,"score_spread":0.2235255170031402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}