{"id":"W3015451581","doi":"10.1128/iai.00017-20","title":"Salmonella enterica Infection of Murine and Human Enteroid-Derived Monolayers Elicits Differential Activation of Epithelium-Intrinsic Inflammasomes","year":2020,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; NIH Office of the Director; Canadian Institutes of Health Research; Government of Canada; National Institutes of Health; Crohn's and Colitis Canada; University of Washington","keywords":"Inflammasome; Salmonella enterica; Biology; Salmonella; Microbiology; Caspase 1; Signal transduction; Caspase; Intestinal epithelium; Cell biology; Apoptosis; Epithelium; Immunology; Programmed cell death; Inflammation; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006596655,0.00013753,0.0001954281,0.00007522125,0.0001031865,0.00001370525,0.00004345718,0.0001032654,0.00002167303],"category_scores_gemma":[0.00006445485,0.0001385912,0.00006955475,0.00009533594,0.0001071856,0.00001952028,0.0001184568,0.0001138485,7.714039e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000064475,"about_ca_system_score_gemma":0.0000126274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008458926,"about_ca_topic_score_gemma":0.00003382819,"domain_scores_codex":[0.9992913,0.00009952323,0.0002743545,0.0001601127,0.00006827577,0.000106418],"domain_scores_gemma":[0.999522,0.000009254347,0.0001905835,0.0001438005,0.0000919704,0.00004243944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001817003,0.00007333004,0.08761244,0.00008200195,0.00008167997,8.071355e-8,0.0003128023,0.00001462685,0.9069808,0.00001635182,0.00002030576,0.004623898],"study_design_scores_gemma":[0.0007671839,0.0005789701,0.3762831,0.00001736966,0.0000186178,0.000001971001,0.00005042469,0.00003066402,0.6214186,0.00001280153,0.0007321868,0.00008813438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986047,0.0000908477,0.0008152294,0.00006819496,0.0000623837,0.0001619211,0.000004372257,0.00001469329,0.0001777257],"genre_scores_gemma":[0.9986936,0.001088787,0.00001216952,0.00005028842,0.00004791282,0.000007428361,0.00007181802,0.0000120409,0.00001595244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2886706,"threshold_uncertainty_score":0.5651584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0112143152957036,"score_gpt":0.2347398322988438,"score_spread":0.2235255170031402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}