{"id":"W3015474692","doi":"10.1080/2162402x.2020.1738812","title":"An innovative plasmacytoid dendritic cell line-based cancer vaccine primes and expands antitumor T-cells in melanoma patients in a first-in-human trial","year":2020,"lang":"en","type":"article","venue":"OncoImmunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Purdue Pharma (Canada)","funders":"Ligue Contre le Cancer; Etablissement Français du Sang; Agence Nationale de la Recherche","keywords":"Medicine; Cancer vaccine; Melanoma; Antigen; Priming (agriculture); Tolerability; Clinical trial; Immune system; Immunology; Cancer; CD8; Cytotoxic T cell; Cancer research; Immunotherapy; Oncology; Internal medicine; In vitro; Adverse effect; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000283663,0.0003789126,0.0008562181,0.0005816174,0.0001293887,0.00002190121,0.0003947523,0.0004655959,0.0003287086],"category_scores_gemma":[0.0001020081,0.000372839,0.00005771979,0.0007412756,0.0002272089,0.0002079558,0.0001005237,0.0007916535,0.00003887925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001584154,"about_ca_system_score_gemma":0.0002824245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00187069,"about_ca_topic_score_gemma":0.001522514,"domain_scores_codex":[0.9971005,0.0007172959,0.0008811454,0.0006028854,0.00004692231,0.0006512079],"domain_scores_gemma":[0.9990076,0.0003231225,0.0002430355,0.0003161046,0.00008533078,0.00002485223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.06066582,0.001975066,0.1116159,0.00006344701,0.00007702372,0.0000702574,0.004275338,0.0000652082,0.8181159,0.00004961109,0.00007670569,0.002949693],"study_design_scores_gemma":[0.188657,0.008779621,0.2188406,0.0001928334,0.0000213143,0.000008356015,0.0006628022,0.00006164282,0.5761346,0.00002275797,0.005961228,0.0006572619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913318,0.006576049,0.00000755557,0.0004721555,0.0005475783,0.0008816566,0.00004631703,0.00004645678,0.00009042268],"genre_scores_gemma":[0.9980503,0.0008427256,0.00004004015,0.0005315386,0.00002780184,0.0001908776,0.0001571194,0.0000415759,0.000117996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2419813,"threshold_uncertainty_score":0.9998723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01301881395608543,"score_gpt":0.2663258182441964,"score_spread":0.2533070042881109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}