{"id":"W3015474692","doi":"10.1080/2162402x.2020.1738812","title":"An innovative plasmacytoid dendritic cell line-based cancer vaccine primes and expands antitumor T-cells in melanoma patients in a first-in-human trial","year":2020,"lang":"en","type":"article","venue":"OncoImmunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Purdue Pharma (Canada)","funders":"Ligue Contre le Cancer; Etablissement Français du Sang; Agence Nationale de la Recherche","keywords":"Medicine; Cancer vaccine; Melanoma; Antigen; Priming (agriculture); Tolerability; Clinical trial; Immune system; Immunology; Cancer; CD8; Cytotoxic T cell; Cancer research; Immunotherapy; Oncology; Internal medicine; In vitro; Adverse effect; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008870596,0.0007093598,0.001102253,0.0002479862,0.0002907354,0.0007659646,0.0004118359,0.0009904423,0.001056777],"category_scores_gemma":[0.0004165181,0.0002344667,0.0005436974,0.000191564,0.0004421991,0.000373066,0.0002616193,0.001892494,0.0002732969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004269089,"about_ca_system_score_gemma":0.0007741422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003381146,"about_ca_topic_score_gemma":0.0004740459,"domain_scores_codex":[0.9997446,0.0001022094,0.00001576508,0.00003762315,0.00003126273,0.00006864704],"domain_scores_gemma":[0.9997839,0.00003234852,0.0000288793,0.00002399797,0.00002089733,0.0001100853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3419708,0.1152735,0.008061217,0.001652157,0.0009413838,0.0009747183,0.0006657662,0.00446859,0.2589736,0.001173897,0.006264526,0.2595798],"study_design_scores_gemma":[0.1528062,0.798815,0.006052626,0.00006644979,0.0003552047,0.0005523788,0.00005895783,0.002050808,0.03255549,0.0002494658,0.006413646,0.00002371309],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939074,0.001882711,0.0008187323,0.0003469307,0.0001827343,0.001537405,0.0002310551,0.00007752111,0.001015672],"genre_scores_gemma":[0.9943373,0.001357339,0.001167406,0.0004488957,0.0001332608,0.0008925705,0.0004756342,0.00001394648,0.001173718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001102253,"threshold_uncertainty_score":0.004691303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01301881395608543,"score_gpt":0.2663258182441964,"score_spread":0.2533070042881109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}