{"id":"W3015483118","doi":"10.1016/j.jhep.2020.03.047","title":"C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelle","year":2020,"lang":"en","type":"article","venue":"Journal of Hepatology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsche Forschungsgemeinschaft; Deutsches Krebsforschungszentrum; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Helmholtz-Alberta Initiative; California Department of Fish and Game; National Science Foundation","keywords":"Biology; Viral replication; Hepatitis C virus; Interferon; Virology; Subgenomic mRNA; Gene expression profiling; Transcriptome; Replicon; Interferon-stimulated gene; Gene expression; Virus; Molecular biology; Gene; Immunology; RNA; Genetics; Innate immune system; Genome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003873977,0.00009564483,0.0003979151,0.0001565782,0.00004098231,0.000006512385,0.0003250841,0.0001651909,0.00007937399],"category_scores_gemma":[0.001243986,0.00006868246,0.0001404086,0.0004027749,0.00007548112,0.0003271349,0.0001172,0.000381145,0.000007482781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000111244,"about_ca_system_score_gemma":0.0003616922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000469557,"about_ca_topic_score_gemma":0.00001269915,"domain_scores_codex":[0.9980847,0.0002563796,0.0008353246,0.0001974426,0.0004771474,0.0001490206],"domain_scores_gemma":[0.9974777,0.00005414773,0.001076259,0.0007759607,0.000477079,0.0001388951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007518526,0.0001860046,0.3557933,0.0002094181,0.00004348677,0.000007096892,0.001910931,0.000002353916,0.6200581,0.00008756821,0.006545161,0.0144048],"study_design_scores_gemma":[0.001052962,0.001399449,0.02753938,0.0001259575,0.00005608351,0.0001179455,0.0001287544,0.001447776,0.964893,0.0001161989,0.003065997,0.00005649481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845755,0.00005362927,0.0002346757,0.01399448,0.0001491084,0.0003230804,0.000008158015,0.00000960437,0.0006517255],"genre_scores_gemma":[0.998556,0.00008622747,0.0004092535,0.0007594998,0.0001266645,0.000003416676,0.000006040492,0.00001766006,0.00003528163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.344835,"threshold_uncertainty_score":0.2800789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1217037147065915,"score_gpt":0.356155752652047,"score_spread":0.2344520379454555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}