{"id":"W3015483118","doi":"10.1016/j.jhep.2020.03.047","title":"C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelle","year":2020,"lang":"en","type":"article","venue":"Journal of Hepatology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsche Forschungsgemeinschaft; Deutsches Krebsforschungszentrum; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Helmholtz-Alberta Initiative; California Department of Fish and Game; National Science Foundation","keywords":"Biology; Viral replication; Hepatitis C virus; Interferon; Virology; Subgenomic mRNA; Gene expression profiling; Transcriptome; Replicon; Interferon-stimulated gene; Gene expression; Virus; Molecular biology; Gene; Immunology; RNA; Genetics; Innate immune system; Genome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002963202,0.0007304859,0.0004157676,0.0004799055,0.0005453099,0.0005315867,0.0003109883,0.0006176826,0.004272113],"category_scores_gemma":[0.0003767165,0.0002056832,0.00059672,0.0003396175,0.0004779367,0.0002472037,0.0003675363,0.0005350694,0.001685734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007065641,"about_ca_system_score_gemma":0.0003656847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0011294,"about_ca_topic_score_gemma":0.001127568,"domain_scores_codex":[0.9996996,0.00003074803,0.00002768966,0.00008240023,0.00009584282,0.00006385531],"domain_scores_gemma":[0.9996411,0.00005084868,0.0001702189,0.00003331146,0.00003662787,0.00006802235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004217192,0.00003225881,0.001986167,0.0002602112,0.00003475935,0.000461303,0.0000194241,0.0002623104,0.9851156,0.0006004669,0.001204689,0.009601067],"study_design_scores_gemma":[0.00008109079,0.0004026154,0.02314471,0.00006024041,0.0000688908,0.003159021,0.00002878184,0.001916937,0.9302279,0.000260667,0.04061196,0.00003728422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9315306,0.0222804,0.0201905,0.0007212183,0.0004857073,0.0003117275,0.007904914,0.001303425,0.01527148],"genre_scores_gemma":[0.9752585,0.003853473,0.006287818,0.0002765284,0.00008321113,0.000103009,0.006776863,0.0001561772,0.007204363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004272113,"threshold_uncertainty_score":0.01429158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1217037147065915,"score_gpt":0.356155752652047,"score_spread":0.2344520379454555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}