{"id":"W3015486681","doi":"10.1038/s41467-020-17312-3","title":"Multivariate genomic scan implicates novel loci and haem metabolism in human ageing","year":2020,"lang":"en","type":"review","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research","funders":"Medical Research Council; University of Edinburgh; Alexander von Humboldt-Stiftung","keywords":"Multivariate statistics; Ageing; Computational biology; Biology; Genetics; Multivariate analysis; Evolutionary biology; Bioinformatics; Computer science; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008473836,0.000636347,0.00125957,0.001570526,0.0001355014,0.0005765941,0.0007767844,0.0008794244,0.002162697],"category_scores_gemma":[0.001348548,0.0002181959,0.0005607861,0.00152047,0.0004629419,0.0006091038,0.000465274,0.001188991,0.0009906377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004979232,"about_ca_system_score_gemma":0.001024399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001461637,"about_ca_topic_score_gemma":0.002389865,"domain_scores_codex":[0.9997912,0.00004640503,0.00003312738,0.00006282817,0.00005244371,0.00001402252],"domain_scores_gemma":[0.9992249,0.0004749908,0.00008933012,0.00002303762,0.0001430522,0.00004461612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0001692808,0.0000180134,0.001351926,0.008815478,0.0004293414,0.0003713224,0.00003260722,0.0004087715,0.001201494,0.002623255,0.02239459,0.9621839],"study_design_scores_gemma":[0.00007200193,0.0002323896,0.01476649,0.005294927,0.001449948,0.006531724,0.0001061761,0.0004764544,0.001582573,0.006712961,0.9626999,0.00007443197],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002504132,0.9980254,0.0003828968,0.0005594424,0.000174967,0.000003332298,0.00004821663,0.00001272892,0.0005426671],"genre_scores_gemma":[0.003035396,0.9948325,0.0006461332,0.0004193968,0.0003649678,0.00000818758,0.0001175159,0.000004610603,0.0005712708],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002162697,"threshold_uncertainty_score":0.007234931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04725065312384285,"score_gpt":0.3718220931165199,"score_spread":0.3245714399926771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}