{"id":"W3015554176","doi":"10.1074/jbc.ra120.013679","title":"Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency","year":2020,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1023,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"RNA-dependent RNA polymerase; RNA polymerase; Virology; RNA; Coronavirus; Biology; RNA virus; Favipiravir; Gene; Biochemistry; Medicine; Coronavirus disease 2019 (COVID-19); Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002694997,0.0005545637,0.000412203,0.0002724261,0.0001243585,0.0002248947,0.0003544989,0.0003142683,0.001064419],"category_scores_gemma":[0.0001336792,0.0001534226,0.0002902937,0.0001132528,0.0001582537,0.0001088761,0.0001211768,0.0004683133,0.0006133611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002671836,"about_ca_system_score_gemma":0.0001840123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003745338,"about_ca_topic_score_gemma":0.001232098,"domain_scores_codex":[0.9998382,0.0000377352,0.00001498294,0.00002983299,0.00004804216,0.00003114183],"domain_scores_gemma":[0.9999443,0.00001331743,0.00001450423,0.00000889476,0.000008244348,0.00001069092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000282796,0.0001071162,0.0004371345,0.0002353049,0.00003000397,0.0001758573,0.00001655116,0.0003473328,0.9740462,0.0002819657,0.0003006798,0.02373904],"study_design_scores_gemma":[0.0002689837,0.0046022,0.004765028,0.00002175418,0.00004913418,0.002851235,0.00001428667,0.001066517,0.9645159,0.0001115778,0.02171404,0.00001945018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9226462,0.03753851,0.01202874,0.000336346,0.0002542934,0.0005052693,0.002088148,0.0007181159,0.02388444],"genre_scores_gemma":[0.9733925,0.00719115,0.01106887,0.0001949974,0.00007894123,0.0001311793,0.002335357,0.00003273704,0.005574374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001064419,"threshold_uncertainty_score":0.003560841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0712352523113213,"score_gpt":0.3192657732167987,"score_spread":0.2480305209054774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}