{"id":"W3015616260","doi":"10.3389/fcimb.2020.00154","title":"Trypanosoma brucei and Trypanosoma cruzi DNA Mismatch Repair Proteins Act Differently in the Response to DNA Damage Caused by Oxidative Stress","year":2020,"lang":"en","type":"article","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Universidade Federal de Minas Gerais; Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Wellcome Trust; McGill University","keywords":"Trypanosoma cruzi; Trypanosoma brucei; DNA damage; Oxidative stress; DNA; Biology; DNA repair; Virology; Genetics; Gene; Biochemistry; Parasite hosting","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000104967,0.0002731356,0.0003746045,0.0002317969,0.0001297098,0.0003073385,0.0001481434,0.0003656222,0.0006183293],"category_scores_gemma":[0.0001224341,0.0001473414,0.0002476762,0.000150411,0.0001805773,0.0001768444,0.0002238178,0.0003177038,0.0002422102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001805129,"about_ca_system_score_gemma":0.00009935205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005325056,"about_ca_topic_score_gemma":0.0006902003,"domain_scores_codex":[0.9998141,0.00002176591,0.00001848905,0.0000391402,0.00005838168,0.00004814057],"domain_scores_gemma":[0.9998877,0.00001005565,0.00003278506,0.000008020186,0.00001939953,0.00004205492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001093542,0.000006396015,0.0005092986,0.00001832105,0.000002783741,0.00004877077,0.00001835869,0.000008031602,0.9989856,0.00002014594,0.00001023027,0.0002627735],"study_design_scores_gemma":[0.00003535327,0.0005319993,0.1105672,0.00001704939,0.0000547725,0.001269567,0.0002635733,0.0007480145,0.8833579,0.0001135879,0.003023101,0.00001784946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997182,0.001243567,0.0005072413,0.00006748447,0.00001910356,0.00001065918,0.0002729006,0.00002003479,0.0006769322],"genre_scores_gemma":[0.9956803,0.0008328154,0.0008416509,0.0001019733,0.00001089383,0.0000250163,0.0007322973,0.00001403191,0.001760834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006183293,"threshold_uncertainty_score":0.00206852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01360317880536786,"score_gpt":0.2531729892672794,"score_spread":0.2395698104619115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}