{"id":"W3015651558","doi":"10.1172/jci.insight.132446","title":"Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium","year":2020,"lang":"en","type":"article","venue":"JCI Insight","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec; Université Laval; St. Paul's Hospital","funders":"NIHR Nottingham Biomedical Research Centre; Medical Research Council; Manchester Biomedical Research Centre; Lung Foundation Netherlands; Universitair Medisch Centrum Groningen; Ministerie van Volksgezondheid, Welzijn en Sport; University of Nottingham; National Institutes of Health; Rijksuniversiteit Groningen; Rosetrees Trust; Trent University; Asthma and Lung UK; National Institute for Health and Care Research; British Lung Foundation; Nottingham Trent University","keywords":"Single-nucleotide polymorphism; Biology; Phenotype; Asthma; Immunology; Genome-wide association study; Medicine; Genetics; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007607093,0.0001289749,0.0002467925,0.00008536581,0.00006644052,0.000006446509,0.00004596958,0.0001670664,0.0002294035],"category_scores_gemma":[0.00003050119,0.0001143116,0.00002324194,0.0001444211,0.0001378592,0.0001126929,0.00002518739,0.0001687608,0.00005419694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001063295,"about_ca_system_score_gemma":0.00003996482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004903103,"about_ca_topic_score_gemma":0.00004337914,"domain_scores_codex":[0.9992387,0.00008911321,0.0002587579,0.0002161142,0.00003390316,0.0001634086],"domain_scores_gemma":[0.9997073,0.0000790256,0.0000712747,0.00008773029,0.00002742824,0.00002727918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002805761,0.00008799586,0.002454443,0.0001705676,0.00006440817,0.000006801946,0.0085951,0.00001358628,0.9705786,0.00166327,0.0006934332,0.01539124],"study_design_scores_gemma":[0.008939842,0.001456077,0.1123873,0.0002260071,0.0001679282,0.0001231982,0.0007243876,0.0005627679,0.6999431,0.001307209,0.1733152,0.0008469559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809657,0.01203664,0.002008428,0.0008883008,0.0003426445,0.000279799,0.0002232763,0.00003965297,0.00321561],"genre_scores_gemma":[0.9991439,0.0001595968,0.0001085016,0.0002242017,0.00004697128,0.000007358499,0.00006744869,0.00001134907,0.0002306671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2706354,"threshold_uncertainty_score":0.4661492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01799800744262878,"score_gpt":0.2086624253366507,"score_spread":0.1906644178940219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}