{"id":"W3015651558","doi":"10.1172/jci.insight.132446","title":"Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium","year":2020,"lang":"en","type":"article","venue":"JCI Insight","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec; Université Laval; St. Paul's Hospital","funders":"NIHR Nottingham Biomedical Research Centre; Medical Research Council; Manchester Biomedical Research Centre; Lung Foundation Netherlands; Universitair Medisch Centrum Groningen; Ministerie van Volksgezondheid, Welzijn en Sport; University of Nottingham; National Institutes of Health; Rijksuniversiteit Groningen; Rosetrees Trust; Trent University; Asthma and Lung UK; National Institute for Health and Care Research; British Lung Foundation; Nottingham Trent University","keywords":"Single-nucleotide polymorphism; Biology; Phenotype; Asthma; Immunology; Genome-wide association study; Medicine; Genetics; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003619769,0.0003106247,0.0002372407,0.0003028717,0.000124449,0.0003653827,0.0001641745,0.0003197177,0.001619191],"category_scores_gemma":[0.0005904433,0.000208806,0.0003174307,0.0001752142,0.0002805786,0.0000820139,0.0002717095,0.0004452935,0.0003293018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001560404,"about_ca_system_score_gemma":0.000114978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005876864,"about_ca_topic_score_gemma":0.0008871678,"domain_scores_codex":[0.9995663,0.0001241669,0.00004733437,0.0001187861,0.00009606098,0.00004744044],"domain_scores_gemma":[0.9995332,0.0001364997,0.0001621472,0.00008048533,0.00003040361,0.00005728176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002892002,0.00001245743,0.01008876,0.00002651842,0.0000162034,0.0001829374,0.00004276024,0.00008494341,0.9885122,0.00003484518,0.00002993764,0.0006793179],"study_design_scores_gemma":[0.00005736509,0.0003161163,0.833286,0.00001725929,0.00006898097,0.0021521,0.0001300783,0.0007746931,0.1617839,0.0001227723,0.001276023,0.00001475233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974586,0.0004918581,0.00073516,0.00005914155,0.000008117416,0.00001139188,0.0008876026,0.00001697301,0.0003313156],"genre_scores_gemma":[0.9980427,0.0001258152,0.0006170052,0.0000375052,0.000006488694,0.00001342377,0.000737005,0.00001666383,0.0004031849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001619191,"threshold_uncertainty_score":0.005416751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01799800744262878,"score_gpt":0.2086624253366507,"score_spread":0.1906644178940219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}