{"id":"W3015654418","doi":"10.1002/cpsc.109","title":"Generation and Characterization of Patient‐Derived Head and Neck, Oral, and Esophageal Cancer Organoids","year":2020,"lang":"en","type":"article","venue":"Current Protocols in Stem Cell Biology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal General Hospital; Université de Sherbrooke","funders":"National Institute of Dental and Craniofacial Research; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Alcohol Abuse and Alcoholism; University of Pennsylvania; Ministry of Education, Culture, Sports, Science and Technology; National Institute of Environmental Health Sciences; American Cancer Society; National Cancer Institute; National Science Foundation","keywords":"Esophageal cancer; Organoid; Cancer; Medicine; Head and neck cancer; Cancer research; Adenocarcinoma; Oncology; Pathology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005487689,0.0001130741,0.0003033499,0.00004532824,0.00002382084,0.000009644361,0.00002222993,0.00006948352,0.0000348669],"category_scores_gemma":[0.000004982944,0.00009459122,0.00001411572,0.0001089718,0.00008093931,0.00004950692,0.00005509994,0.00009280166,4.92523e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001736876,"about_ca_system_score_gemma":0.00005228035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002379562,"about_ca_topic_score_gemma":0.00001305345,"domain_scores_codex":[0.9992267,0.00006548998,0.0002690499,0.0002709906,0.00004850944,0.0001191888],"domain_scores_gemma":[0.9996607,0.000008870939,0.0001223242,0.00007263818,0.00004610172,0.00008936533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001625235,0.00005587993,0.0650877,0.0006357802,0.000006484149,0.000001179754,0.0006367338,3.713116e-7,0.7345271,0.00002005318,0.00001242927,0.1988538],"study_design_scores_gemma":[0.005648039,0.002104566,0.03019151,0.000309311,0.0000557305,0.000005391772,0.00008904596,0.0006585445,0.9205725,0.000008247704,0.04013534,0.0002217417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823709,0.001397769,0.00008474945,0.000186532,0.00007022932,0.01582024,0.00004471887,0.000009441002,0.00001539552],"genre_scores_gemma":[0.9897897,0.001057334,0.0001370845,0.0001644303,0.00008556015,0.008669371,0.00007859452,0.00001077544,0.000007203064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1986321,"threshold_uncertainty_score":0.3857318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08025889884091078,"score_gpt":0.3521568528883904,"score_spread":0.2718979540474796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}