{"id":"W3015664414","doi":"10.1007/s00203-020-01873-4","title":"Effect of changes at the conserved + 3 position of mature archaellins on in vitro cleavage by the pre-archaellin peptidase FlaK of Methanococcus maripaludis","year":2020,"lang":"en","type":"article","venue":"Archives of Microbiology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Signal peptidase; Signal peptide; Cleavage (geology); Pilin; Biology; Pilus; Biochemistry; Peptide; Amino acid; Conserved sequence; Methanococcus; Peptide sequence; Cell biology; Archaea; Gene; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002293678,0.000170828,0.000391363,0.00005264892,0.00002492169,0.000001129061,0.0004345562,0.0002334543,0.00001008206],"category_scores_gemma":[0.00007606293,0.0001028001,0.0001418633,0.00009079309,0.001158056,7.827389e-7,0.0003604672,0.0001750463,7.538841e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003299292,"about_ca_system_score_gemma":0.00002295806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006553002,"about_ca_topic_score_gemma":0.0001397228,"domain_scores_codex":[0.998591,0.0005522486,0.0003399179,0.0002793671,0.00003852636,0.0001989158],"domain_scores_gemma":[0.9989915,0.0002712281,0.0003178181,0.0003697124,0.00002229008,0.00002737536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004611542,0.00006386631,0.0002019581,0.0001621049,0.00009729471,7.856016e-7,0.0003741235,0.00001325383,0.9901879,0.00002889255,0.000220924,0.004037398],"study_design_scores_gemma":[0.0008050159,0.003610654,0.0008120467,0.00003403974,0.00003485168,0.000008427226,0.00003793047,0.00001725626,0.9931346,0.00004416001,0.001375292,0.00008576945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945433,0.001370914,0.00004984703,0.002509561,0.00004398187,0.0004683408,0.0009439213,0.000002912276,0.000067211],"genre_scores_gemma":[0.9983808,0.0007580232,0.0001486778,0.0001997738,0.00002886452,0.00001466211,0.0004114995,0.0000132459,0.000044394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003951629,"threshold_uncertainty_score":0.4266905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00505928647911438,"score_gpt":0.2162021424195317,"score_spread":0.2111428559404173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}