{"id":"W3015669461","doi":"10.1001/jamapsychiatry.2020.0527","title":"Genetic Associations Between Childhood Psychopathology and Adult Depression and Associated Traits in 42 998 Individuals","year":2020,"lang":"en","type":"review","venue":"JAMA Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institute of Mental Health; Institut d’Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona; Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg; Helmholtz Zentrum München; Instituto de Salud Carlos III; Medical Research Council; Montreal Neurological Institute and Hospital; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; State University of New York Upstate Medical University; Campbell Family Mental Health Research Institute; School of Medicine, Indiana University; Statens Serum Institut; SUNY Downstate Medical Center; Veterans Affairs San Diego Healthcare System; University of California, Irvine; University of California, San Diego; University of North Carolina at Chapel Hill; Karolinska Institutet; University of Illinois at Urbana-Champaign; Institut National de la Santé et de la Recherche Médicale; H. Lundbeck A/S; School of Medicine, Stanford University; Assistance publique-Hôpitaux de Paris; Universitätsklinikum Köln; Julius-Maximilians-Universität Würzburg; Janssen Research and Development; Diakonhjemmet; Universiteit Leiden; Centre Hospitalier Universitaire Vaudois; Göteborgs Universitet; Háskóli Íslands; Neuroscience Research Australia; Leids Universitair Medisch Centrum; NHLBI Division of Intramural Research; Universitätsmedizin Göttingen; Bundesinstitut für Arzneimittel und Medizinprodukte; Universitetet i Bergen; Umeå Universitet; Rheinische Friedrich-Wilhelms-Universität Bonn; Westfälische Wilhelms-Universität Münster; Queensland University of Technology; Universitair Medisch Centrum Utrecht; F. Hoffmann-La Roche; University of Toronto; GGZ inGeest; Albert-Ludwigs-Universität Freiburg; Dalhousie University; Technische Universität München; School of Medicine, Emory University; King's College London; Gentofte Hospital; Vrije Universiteit Amsterdam; Rijksuniversiteit Groningen; McGill University Health Centre; Trinity College Dublin; Rigshospitalet; Università degli Studi di Trento; Newcastle University; Universitat de Barcelona; Universiteit Utrecht; Norges Teknisk-Naturvitenskapelige Universitet; Tartu Ülikool; Université Paris Diderot; University of Galway; Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu; Dokuz Eylül Üniversitesi; Universität Duisburg-Essen; Broad Institute; University of Oxford; Universitat Autònoma de Barcelona; McGill University; University of Worcester; Queen Mary University of London; QIMR Berghofer Medical Research Institute; Vanderbilt University Medical Center; University of New South Wales; Washington University in St. Louis; University of Pittsburgh; U.S. Department of Veterans Affairs; National University of Ireland; Virginia Commonwealth University; Aarhus Universitet; Massachusetts Institute of Technology; Universität Basel; Cardiff University; Syracuse University; James Cook University; Kaiser Permanente; Technische Universität Dresden; Universiteit Antwerpen; Brigham and Women's Hospital; State University of New York; Università di Bologna; University of Aberdeen; University College London; Massachusetts General Hospital; University of Minnesota; Rush University; Emory University; University of Queensland; Harvard T.H. Chan School of Public Health; NIH Clinical Center; Universidad de Granada; Johns Hopkins Bloomberg School of Public Health; Aarhus Universitetshospital; Eberhard Karls Universität Tübingen; University of Glasgow; University of Pennsylvania; Philipps-Universität Marburg; Vanderbilt University; University of California, Los Angeles; Pfizer; Lundbeckfonden; Universitetet i Oslo; Wellcome Trust; Johns Hopkins University; Amgen; Université de Lausanne; University of Southern California","keywords":"Psychopathology; Depression (economics); Psychology; Clinical psychology; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005495422,0.0009844383,0.001859546,0.00163119,0.0005876357,0.001215584,0.0008420668,0.0008418426,0.001255854],"category_scores_gemma":[0.0072771,0.0009509691,0.007309532,0.003241965,0.0004044759,0.0004224148,0.0007643929,0.0007200786,0.0001446733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004394988,"about_ca_system_score_gemma":0.000465104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0102748,"about_ca_topic_score_gemma":0.01447841,"domain_scores_codex":[0.9965917,0.001536017,0.0005312167,0.0009135645,0.0002987191,0.0001289743],"domain_scores_gemma":[0.996492,0.002006989,0.0006671305,0.0004696554,0.0002638753,0.0001004466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002423764,0.00003883727,0.7145374,0.002288152,0.266794,0.0003584732,0.0001936325,0.0006845331,0.0009399023,0.0001580783,0.0009505255,0.01063275],"study_design_scores_gemma":[0.0007371167,0.0004328274,0.6434118,0.001193174,0.3488922,0.0005784799,0.0001841986,0.0009826934,0.0004996558,0.0004711825,0.002585365,0.00003139089],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8020685,0.1841928,0.004734614,0.0006069268,0.0002320605,0.000171724,0.006416559,0.0001201945,0.00145652],"genre_scores_gemma":[0.9856499,0.01057067,0.001452102,0.0001924321,0.00004858578,0.000127706,0.001661195,0.00002069039,0.0002766725],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.0102748,"threshold_uncertainty_score":0.02906287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01501179559872852,"score_gpt":0.2981743217978886,"score_spread":0.28316252619916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}