{"id":"W3015669461","doi":"10.1001/jamapsychiatry.2020.0527","title":"Genetic Associations Between Childhood Psychopathology and Adult Depression and Associated Traits in 42 998 Individuals","year":2020,"lang":"en","type":"review","venue":"JAMA Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institute of Mental Health; Institut d’Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona; Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg; Helmholtz Zentrum München; Instituto de Salud Carlos III; Medical Research Council; Montreal Neurological Institute and Hospital; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; State University of New York Upstate Medical University; Campbell Family Mental Health Research Institute; School of Medicine, Indiana University; Statens Serum Institut; SUNY Downstate Medical Center; Veterans Affairs San Diego Healthcare System; University of California, Irvine; University of California, San Diego; University of North Carolina at Chapel Hill; Karolinska Institutet; University of Illinois at Urbana-Champaign; Institut National de la Santé et de la Recherche Médicale; H. Lundbeck A/S; School of Medicine, Stanford University; Assistance publique-Hôpitaux de Paris; Universitätsklinikum Köln; Julius-Maximilians-Universität Würzburg; Janssen Research and Development; Diakonhjemmet; Universiteit Leiden; Centre Hospitalier Universitaire Vaudois; Göteborgs Universitet; Háskóli Íslands; Neuroscience Research Australia; Leids Universitair Medisch Centrum; NHLBI Division of Intramural Research; Universitätsmedizin Göttingen; Bundesinstitut für Arzneimittel und Medizinprodukte; Universitetet i Bergen; Umeå Universitet; Rheinische Friedrich-Wilhelms-Universität Bonn; Westfälische Wilhelms-Universität Münster; Queensland University of Technology; Universitair Medisch Centrum Utrecht; F. Hoffmann-La Roche; University of Toronto; GGZ inGeest; Albert-Ludwigs-Universität Freiburg; Dalhousie University; Technische Universität München; School of Medicine, Emory University; King's College London; Gentofte Hospital; Vrije Universiteit Amsterdam; Rijksuniversiteit Groningen; McGill University Health Centre; Trinity College Dublin; Rigshospitalet; Università degli Studi di Trento; Newcastle University; Universitat de Barcelona; Universiteit Utrecht; Norges Teknisk-Naturvitenskapelige Universitet; Tartu Ülikool; Université Paris Diderot; University of Galway; Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu; Dokuz Eylül Üniversitesi; Universität Duisburg-Essen; Broad Institute; University of Oxford; Universitat Autònoma de Barcelona; McGill University; University of Worcester; Queen Mary University of London; QIMR Berghofer Medical Research Institute; Vanderbilt University Medical Center; University of New South Wales; Washington University in St. Louis; University of Pittsburgh; U.S. Department of Veterans Affairs; National University of Ireland; Virginia Commonwealth University; Aarhus Universitet; Massachusetts Institute of Technology; Universität Basel; Cardiff University; Syracuse University; James Cook University; Kaiser Permanente; Technische Universität Dresden; Universiteit Antwerpen; Brigham and Women's Hospital; State University of New York; Università di Bologna; University of Aberdeen; University College London; Massachusetts General Hospital; University of Minnesota; Rush University; Emory University; University of Queensland; Harvard T.H. Chan School of Public Health; NIH Clinical Center; Universidad de Granada; Johns Hopkins Bloomberg School of Public Health; Aarhus Universitetshospital; Eberhard Karls Universität Tübingen; University of Glasgow; University of Pennsylvania; Philipps-Universität Marburg; Vanderbilt University; University of California, Los Angeles; Pfizer; Lundbeckfonden; Universitetet i Oslo; Wellcome Trust; Johns Hopkins University; Amgen; Université de Lausanne; University of Southern California","keywords":"Psychopathology; Depression (economics); Psychology; Clinical psychology; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0005631106,0.0005450808,0.001694929,0.0001999275,0.0001622474,0.00005747743,0.0003094817,0.001930011,0.000007516331],"category_scores_gemma":[0.001063124,0.0005218395,0.0002691039,0.0003330767,0.00009015484,0.000006695933,0.0002537072,0.000726655,0.00001151722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004609167,"about_ca_system_score_gemma":0.0003427538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002591903,"about_ca_topic_score_gemma":0.000172918,"domain_scores_codex":[0.9961924,0.0009265668,0.001113173,0.001067939,0.0001637177,0.0005362081],"domain_scores_gemma":[0.9983438,0.0001585074,0.0008963639,0.0003099475,0.00007178263,0.0002195573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.000003205597,0.0001187174,0.481361,0.0003253799,0.0003839037,0.000002503903,0.0001128515,9.563106e-7,0.000002821882,0.00002435123,0.005095103,0.5125692],"study_design_scores_gemma":[0.001164929,0.0001752034,0.8403945,0.0006603213,0.0005344065,0.0000319769,0.00002938555,0.000002341073,2.084356e-7,0.0005507902,0.1559642,0.0004917313],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.06178384,0.9349421,0.00005427085,0.0008841763,0.000286752,0.0007203325,0.001067031,0.00002577936,0.0002357563],"genre_scores_gemma":[0.009243419,0.9841668,0.002960929,0.0007590384,0.0008708097,0.0001290842,0.00173731,0.0000866163,0.00004601333],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5120775,"threshold_uncertainty_score":0.9997233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01501179559872852,"score_gpt":0.2981743217978886,"score_spread":0.28316252619916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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