{"id":"W3015703032","doi":"10.1093/brain/awaa084","title":"NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients","year":2020,"lang":"en","type":"article","venue":"Brain","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"H2020 European Research Council; Red Española de Esclerosis Múltiple; Ministerio de Ciencia e Innovación","keywords":"Inflammasome; Multiple sclerosis; Medicine; Primary (astronomy); Oncology; Neuroscience; Internal medicine; Immunology; Psychology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004943727,0.0002425467,0.0006830674,0.000339394,0.0002653477,0.0004332821,0.0001539835,0.0003377548,0.0008449306],"category_scores_gemma":[0.001065218,0.0001080857,0.0002553076,0.0003570894,0.0001540016,0.0002320826,0.0002054787,0.0002871923,0.0002081379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000216705,"about_ca_system_score_gemma":0.0002423661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003568026,"about_ca_topic_score_gemma":0.0004506224,"domain_scores_codex":[0.9997607,0.00007550375,0.00002486202,0.00006566927,0.00003830974,0.0000349654],"domain_scores_gemma":[0.9996229,0.00009737195,0.0001246301,0.00002501778,0.00005087153,0.0000791257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0101133,0.0003058948,0.929355,0.0001733609,0.0002252451,0.001551268,0.0002159096,0.0003259211,0.02002425,0.00007038465,0.0006145334,0.03702487],"study_design_scores_gemma":[0.0002078227,0.002082312,0.9903014,0.00003276466,0.0002596657,0.002616997,0.0001341023,0.0008878175,0.002077295,0.0001588698,0.001231361,0.000009630984],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996519,0.002646765,0.0001432969,0.00008075929,0.000009807132,0.00002076471,0.0001572891,0.0000122849,0.0004100556],"genre_scores_gemma":[0.9990859,0.0003213274,0.000143845,0.00004863479,0.00002313026,0.00001411413,0.0002301868,0.000001741361,0.000131277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008449306,"threshold_uncertainty_score":0.002826571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01318847134003919,"score_gpt":0.2089483250673879,"score_spread":0.1957598537273487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}