{"id":"W3015703032","doi":"10.1093/brain/awaa084","title":"NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients","year":2020,"lang":"en","type":"article","venue":"Brain","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"H2020 European Research Council; Red Española de Esclerosis Múltiple; Ministerio de Ciencia e Innovación","keywords":"Inflammasome; Multiple sclerosis; Medicine; Primary (astronomy); Oncology; Neuroscience; Internal medicine; Immunology; Psychology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004987638,0.0001690263,0.0001522975,0.00003367644,0.00004967529,0.00002861363,0.0001297749,0.0001209049,0.00002689387],"category_scores_gemma":[0.000323243,0.0001591724,0.00004920734,0.0001019213,0.00007075997,0.000008038583,0.0001240071,0.0001015955,0.00001998612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000102628,"about_ca_system_score_gemma":0.00006102238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006546779,"about_ca_topic_score_gemma":0.000005377668,"domain_scores_codex":[0.9990349,0.00006670783,0.0001992035,0.0003270852,0.0001114144,0.0002607232],"domain_scores_gemma":[0.9996403,0.0000270335,0.00007161723,0.0001389211,0.00004483408,0.00007729986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002366224,0.0001146662,0.6440141,0.00006023584,0.00004856944,0.000005195841,0.0007696733,0.00001043064,0.3391537,0.00001105335,0.0003650926,0.01521068],"study_design_scores_gemma":[0.00294822,0.0008005582,0.9177141,0.00003720981,0.000008933098,0.000001324895,0.0001440856,0.00008882597,0.06289837,0.00005372886,0.0149486,0.00035611],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967113,0.001546397,0.00002066329,0.0008129734,0.00003938917,0.0005613561,0.00002201208,0.00001611811,0.000269804],"genre_scores_gemma":[0.9966742,0.00005435468,0.0001497068,0.00269202,0.00005511649,0.00006990683,0.0002194606,0.00002681192,0.00005846003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2762554,"threshold_uncertainty_score":0.6490862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01318847134003919,"score_gpt":0.2089483250673879,"score_spread":0.1957598537273487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}