{"id":"W3015773337","doi":"10.1016/j.jaut.2020.102462","title":"Dual-Targeted Autoimmune Sword in Fatal Epilepsy: Patient's glutamate receptor AMPA GluR3B peptide autoimmune antibodies bind, induce Reactive Oxygen Species (ROS) in, and kill both human neural cells and T cells","year":2020,"lang":"en","type":"article","venue":"Journal of Autoimmunity","topic":"Autoimmune Neurological Disorders and Treatments","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Antibody; Immunology; AMPA receptor; Autoantibody; Glutamate receptor; Receptor; Biology; Medicine; Molecular biology; Chemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001971493,0.0005293947,0.000293842,0.0004225607,0.0005371896,0.0002897835,0.0003159079,0.001194948,0.001357352],"category_scores_gemma":[0.0003338445,0.0001662818,0.0003798322,0.0001463216,0.0003604572,0.000263596,0.0002951059,0.0006881432,0.000349995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004934791,"about_ca_system_score_gemma":0.0002143193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001206832,"about_ca_topic_score_gemma":0.001899231,"domain_scores_codex":[0.9998695,0.00001732456,0.00001532174,0.00002671415,0.00001856664,0.00005254444],"domain_scores_gemma":[0.9998714,0.00002547952,0.00001704377,0.00001539508,0.0000202768,0.00005043578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005216733,0.0007284993,0.06300317,0.00021874,0.0001916887,0.7410118,0.0004155955,0.0005665396,0.1483197,0.001158285,0.005053401,0.03411581],"study_design_scores_gemma":[0.0004551635,0.003076363,0.07905627,0.00004859047,0.0002894332,0.8159925,0.0004161452,0.00471342,0.08549097,0.001219739,0.009200327,0.00004113046],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905799,0.0008250129,0.001339095,0.0009587564,0.0001522649,0.00004483154,0.0001422397,0.0001093657,0.005848535],"genre_scores_gemma":[0.9983302,0.000151499,0.0002807846,0.0003577476,0.00002916026,0.000005068381,0.00007349488,0.000007000344,0.0007651487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001357352,"threshold_uncertainty_score":0.004540801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02242292342128418,"score_gpt":0.2491693462760837,"score_spread":0.2267464228547995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}