{"id":"W3015773337","doi":"10.1016/j.jaut.2020.102462","title":"Dual-Targeted Autoimmune Sword in Fatal Epilepsy: Patient's glutamate receptor AMPA GluR3B peptide autoimmune antibodies bind, induce Reactive Oxygen Species (ROS) in, and kill both human neural cells and T cells","year":2020,"lang":"en","type":"article","venue":"Journal of Autoimmunity","topic":"Autoimmune Neurological Disorders and Treatments","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Antibody; Immunology; AMPA receptor; Autoantibody; Glutamate receptor; Receptor; Biology; Medicine; Molecular biology; Chemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005308913,0.000668824,0.001786385,0.0004982731,0.0003469089,0.0001211067,0.0002982269,0.0003341883,0.0001676223],"category_scores_gemma":[0.0003233644,0.0005457769,0.0002725025,0.000680376,0.000551057,0.0006460804,0.00048987,0.002109143,0.00001373757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001769537,"about_ca_system_score_gemma":0.0001474969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005477525,"about_ca_topic_score_gemma":0.00002642514,"domain_scores_codex":[0.9958206,0.0005649758,0.001768424,0.0005320336,0.0005803597,0.0007335492],"domain_scores_gemma":[0.9976432,0.0002788066,0.001149308,0.0004370031,0.0001968248,0.000294801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002779263,0.002029971,0.08491631,0.0002187175,0.0003944552,0.001587607,0.01162558,0.0001776057,0.8908885,0.00003649112,0.0004090279,0.004936531],"study_design_scores_gemma":[0.007410494,0.003877752,0.9682722,0.0003755968,0.0001350999,0.0001797622,0.00300235,0.000574793,0.0136122,0.0001463999,0.001931912,0.0004814225],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927818,0.003679338,0.000004454461,0.001980118,0.0003333702,0.0007248672,0.00007444539,0.00006736295,0.0003542796],"genre_scores_gemma":[0.9965052,0.002068394,0.0003846445,0.0006864492,0.0000546569,0.00000964808,0.00006643285,0.00006961702,0.0001549319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8833559,"threshold_uncertainty_score":0.9996994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02242292342128418,"score_gpt":0.2491693462760837,"score_spread":0.2267464228547995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}