{"id":"W3015836626","doi":"10.1021/acs.jmedchem.0c00003","title":"MymA Bioactivated Thioalkylbenzoxazole Prodrug Family Active against <i>Mycobacterium tuberculosis</i>","year":2020,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Seventh Framework Programme","keywords":"Chemistry; Mycobacterium tuberculosis; Prodrug; Intracellular; Drug discovery; Tuberculosis; Mutant; In vitro; Computational biology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001146825,0.0003136446,0.0002212047,0.0001897635,0.0001274501,0.0001722479,0.0002224367,0.0002020493,0.001227521],"category_scores_gemma":[0.0001249586,0.00009219332,0.0001633513,0.0001762781,0.0001466349,0.000121635,0.0001555383,0.0002993151,0.000405695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003070175,"about_ca_system_score_gemma":0.0002617273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008745719,"about_ca_topic_score_gemma":0.002208953,"domain_scores_codex":[0.9999281,0.00001325344,0.000003265036,0.00001584257,0.00001706168,0.00002253747],"domain_scores_gemma":[0.999952,0.00000509131,0.00001274569,0.000004579381,0.00001194586,0.00001366774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002239572,0.00009838893,0.0006242216,0.0001100837,0.00001516777,0.0002478035,0.00004915566,0.0004091684,0.9800238,0.000379341,0.0004777244,0.01734118],"study_design_scores_gemma":[0.0002106749,0.006837486,0.008336443,0.0000282695,0.00007636828,0.002750065,0.00004591281,0.001375588,0.955224,0.0001270378,0.02496693,0.00002109926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9732539,0.008638939,0.006568385,0.0002369073,0.00006798152,0.0002947218,0.0007806167,0.000234877,0.009923647],"genre_scores_gemma":[0.9870571,0.002226287,0.0047732,0.0001488561,0.0000261206,0.00006278604,0.001260506,0.00001387668,0.00443121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001227521,"threshold_uncertainty_score":0.004106462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02486044110468899,"score_gpt":0.2918617961313175,"score_spread":0.2670013550266285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}