{"id":"W3015856529","doi":"10.1021/acs.orglett.0c01175","title":"Synthesis and Reactions of 3,3-Difluoro-2-<i>exo</i>-methylidene Indolines","year":2020,"lang":"en","type":"article","venue":"Organic Letters","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Kennarshore; University of Toronto; Austrian Science Fund","keywords":"Chemistry; Medicinal chemistry; Combinatorial chemistry; Computational chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002474758,0.0004085368,0.0002684212,0.0002388635,0.0002270064,0.0001419053,0.0006002099,0.0003855141,0.001966428],"category_scores_gemma":[0.0001690274,0.0001726022,0.0002657368,0.0001566378,0.0001749272,0.0003116053,0.00024402,0.0005142816,0.001115323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003050027,"about_ca_system_score_gemma":0.0002195477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005673606,"about_ca_topic_score_gemma":0.001258334,"domain_scores_codex":[0.999799,0.00003129673,0.00001305605,0.0000342582,0.00004096816,0.00008137497],"domain_scores_gemma":[0.9999141,0.00001439356,0.00002163716,0.00001364938,0.00001686349,0.00001944327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001597874,0.00006859826,0.0001642733,0.0002382173,0.00001177499,0.0004305326,0.000158085,0.0003744476,0.9857862,0.001821258,0.0005335865,0.01025319],"study_design_scores_gemma":[0.00002252207,0.0005148666,0.0007393916,0.00001670496,0.00001011806,0.0006795461,0.00002964934,0.000307835,0.9783553,0.0001442183,0.01916079,0.00001911948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.89228,0.01116185,0.05349205,0.0004207187,0.0002059864,0.0003746713,0.002107079,0.0007611986,0.03919643],"genre_scores_gemma":[0.9703101,0.004192207,0.01546873,0.00009146897,0.00002993767,0.0001561797,0.0008760315,0.00008665743,0.008788675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001966428,"threshold_uncertainty_score":0.006578326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06672860961970399,"score_gpt":0.3513921748970379,"score_spread":0.2846635652773339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}