{"id":"W3015885157","doi":"10.1101/2020.04.07.030148","title":"Inflammation promotes adipocyte lipolysis via IRE1 kinase","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China; Indian Council of Medical Research","keywords":"Lipolysis; Adipocyte; Internal medicine; Endocrinology; Adipose tissue; Insulin resistance; Inflammation; Biology; Chemistry; Insulin; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001435596,0.000428423,0.0002860176,0.0002026056,0.0001544404,0.0003132563,0.0001368837,0.0002299167,0.002151075],"category_scores_gemma":[0.00008369437,0.0001482501,0.0002981071,0.0001329902,0.0001860375,0.0003329628,0.0002215205,0.0007798932,0.0005344898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000279929,"about_ca_system_score_gemma":0.0001206768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001319041,"about_ca_topic_score_gemma":0.0001712571,"domain_scores_codex":[0.9998873,0.00001690128,0.00001055892,0.00003134903,0.00002306813,0.00003065965],"domain_scores_gemma":[0.9999083,0.0000133399,0.00003870904,0.000008828345,0.0000100551,0.00002072392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000241812,0.00002113839,0.0001805976,0.00008417838,0.000005011628,0.00003416002,0.000005398806,0.0000386014,0.9986438,0.00006742393,0.0000462123,0.0006316361],"study_design_scores_gemma":[0.00007408849,0.0003744632,0.01684413,0.00003427871,0.00003614288,0.0004625113,0.00003779496,0.000938882,0.9779272,0.0002567649,0.003002248,0.00001150653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827204,0.008626772,0.004401838,0.000470766,0.00009417798,0.00004364144,0.0008918246,0.0001487032,0.002602006],"genre_scores_gemma":[0.9902052,0.003022116,0.002867366,0.0002077085,0.0000378214,0.00005449502,0.0008646377,0.00003417436,0.002706415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002151075,"threshold_uncertainty_score":0.007196069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008597679919201446,"score_gpt":0.2115385172682184,"score_spread":0.202940837349017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}