{"id":"W3015889104","doi":"10.1186/s12885-020-06798-1","title":"Real-world comparative effectiveness of second-line ipilimumab for metastatic melanoma: a population-based cohort study in Ontario, Canada","year":2020,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto; St. Michael's Hospital; Health Sciences Centre; Canadian Centre for Applied Research in Cancer Control; Institute for Clinical Evaluative Sciences; Queen's University; Cancer Care Ontario","funders":"Canadian Institutes of Health Research; Canadian Cancer Society; Government of Ontario; Canadian Centre for Applied Research in Cancer Control; Ontario Ministry of Health and Long-Term Care; Ontario Institute for Cancer Research; Cancer Care Ontario","keywords":"Ipilimumab; Medicine; Internal medicine; Cohort; Population; Oncology; Propensity score matching; Clinical trial; Surgical oncology; Proportional hazards model; Cancer registry; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001803844,0.0003740781,0.0006902684,0.0007501185,0.00176502,0.001027579,0.001222026,0.0004952708,0.001389038],"category_scores_gemma":[0.003640406,0.000378549,0.001094347,0.002923622,0.0008276346,0.0003273811,0.0006616861,0.0006292783,0.0001277837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.03254371,"about_ca_system_score_gemma":0.02396926,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.979297,"about_ca_topic_score_gemma":0.9823711,"domain_scores_codex":[0.9980437,0.0003084515,0.0001665289,0.0004374542,0.0005838469,0.0004600232],"domain_scores_gemma":[0.995915,0.0003572344,0.001626152,0.0002917455,0.001074906,0.0007349261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003799702,0.00004417067,0.9958763,0.00006438376,0.0002914194,0.00009356425,0.0003430118,0.000141707,0.0001492673,0.00009483704,0.0007849137,0.001736376],"study_design_scores_gemma":[0.00008583237,0.00009237635,0.9980251,0.0000319196,0.0001524233,0.00008004493,0.0003404974,0.0003513985,0.00003858311,0.00002460354,0.0007654308,0.0000118479],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927452,0.001072804,0.0001421722,0.0002959863,0.00001074222,0.0001051754,0.004780185,0.000006155796,0.0008415208],"genre_scores_gemma":[0.997775,0.0003589111,0.0001437136,0.0001107752,0.000008693991,0.00003766991,0.001309808,0.000003015169,0.0002524484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03254371,"threshold_uncertainty_score":0.2361223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04038648890419611,"score_gpt":0.3026104423007004,"score_spread":0.2622239533965043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}