{"id":"W3015933272","doi":"10.1128/msphere.00256-20","title":"Oxadiazole-Containing Macrocyclic Peptides Potentiate Azole Activity against Pathogenic <i>Candida</i> Species","year":2020,"lang":"en","type":"article","venue":"mSphere","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"Azole; Fluconazole; Candida albicans; Efflux; Fungal pathogen; Microbiology; Antimicrobial; Biology; Chemistry; Antifungal; Pathogen; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008337924,0.0002383042,0.0001348227,0.0001320261,0.00007345209,0.0001331877,0.0001011664,0.0001360105,0.001519326],"category_scores_gemma":[0.00008501988,0.00005818197,0.0001000108,0.00009379283,0.0001172035,0.0001302331,0.0001007756,0.0002601842,0.0001713768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001002434,"about_ca_system_score_gemma":0.0001074675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003560688,"about_ca_topic_score_gemma":0.0008627685,"domain_scores_codex":[0.9999603,0.000007377495,0.000002489025,0.000005264685,0.000009089796,0.00001545211],"domain_scores_gemma":[0.9999646,0.000007207142,0.000008493976,0.000002228746,0.000004992831,0.00001247567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002365909,0.00006880633,0.0001636451,0.00008180083,0.000006472216,0.00006812649,0.00002277353,0.0002161358,0.9917396,0.0001091086,0.0001131702,0.007173754],"study_design_scores_gemma":[0.00008811588,0.003908316,0.006851969,0.00002041444,0.00003222264,0.0003168321,0.00003947616,0.0005404582,0.9823497,0.00005195957,0.005792045,0.000008701951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991812,0.003850606,0.0006884183,0.00009633178,0.00003842469,0.00002509956,0.000116659,0.00002983599,0.003342741],"genre_scores_gemma":[0.9959408,0.002133409,0.0006392999,0.00007403849,0.00001514364,0.000008136863,0.0001057927,0.000003239109,0.001080031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001519326,"threshold_uncertainty_score":0.005082667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02847863867963116,"score_gpt":0.248045119907039,"score_spread":0.2195664812274079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}