{"id":"W3015933272","doi":"10.1128/msphere.00256-20","title":"Oxadiazole-Containing Macrocyclic Peptides Potentiate Azole Activity against Pathogenic <i>Candida</i> Species","year":2020,"lang":"en","type":"article","venue":"mSphere","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Canada","keywords":"Azole; Fluconazole; Candida albicans; Efflux; Fungal pathogen; Microbiology; Antimicrobial; Biology; Chemistry; Antifungal; Pathogen; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001479323,0.000265461,0.000494067,0.00002121801,0.0002077893,0.00005515955,0.000154349,0.0001266575,0.0006362566],"category_scores_gemma":[0.0001621663,0.0002374689,0.0002886193,0.0002503014,0.0001310589,0.0001776493,0.00009114736,0.0004059315,0.0003675302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009604225,"about_ca_system_score_gemma":0.0001378111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003341425,"about_ca_topic_score_gemma":0.0001938304,"domain_scores_codex":[0.9982851,0.00006378831,0.0002894968,0.0005156808,0.0003614391,0.000484503],"domain_scores_gemma":[0.999,0.00005550971,0.0001105443,0.000373157,0.00007889902,0.0003819109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001292219,0.0001509461,0.3619958,0.000291559,0.0001407735,0.000388007,0.0008289304,0.00002221862,0.6014935,0.0000466743,0.004297501,0.02905188],"study_design_scores_gemma":[0.002730958,0.0005311256,0.9049716,0.0002561806,0.00021005,0.00002021242,0.002829001,0.0007938324,0.05715578,0.00007245579,0.0298314,0.0005974032],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9700254,0.001023659,0.0004438228,0.001823808,0.00009396166,0.0003133628,0.00003650041,0.000190554,0.02604889],"genre_scores_gemma":[0.993322,0.0002904977,0.0003040577,0.003289514,0.0003500615,0.00001196276,0.00002429853,0.00004124555,0.002366383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5443377,"threshold_uncertainty_score":0.9683702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02847863867963116,"score_gpt":0.248045119907039,"score_spread":0.2195664812274079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}